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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3497

Title: Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial.
Other Titles: コンピュータを用いた認知矯正療法は、統合失調症患者の海馬容積を増大する:ランダム化比較対照試験
Authors: Morimoto, Tsubasa
Matsuda, Yasuhiro
Matsuoka, Kiwamu
Yasuno, Fumihiko
Ikebuchi, Emi
Kameda, Hiroyuki
Taoka, Toshiaki
Miyasaka, Toshiteru
Kichikawa, Kimihiko
Kishimoto, Toshifumi
Keywords: Cognitive remediation
Rehabilitation
Structural neuroimaging
Hippocampus
Schizophrenia
Jcores
Issue Date: 27-Mar-2018
Publisher: BioMed Central
Citation: BMC psychiatry Vol.18 No.1 Article No.83 (2018 Mar)
Abstract: BACKGROUND:Cognitive remediation therapy (CRT) effectively reduces neurocognitive impairment in patients with schizophrenia, but few studies have used structural neuroimaging methods to assess its neuroanatomical effects. We investigated these effects, as well as the association between changes in cortical volume and neurocognitive performance. METHOD:Between August 2013 and September 2016, we performed a randomized controlled study comprising a CRT group (16 individuals) and a treatment-as-usual (TAU) group (15 individuals) of patients with schizophrenia. CRT participants engaged in twice-weekly computer-assisted CRT sessions and weekly group meetings for 12 weeks. T1-weighted magnetic resonance imaging was performed before and after the intervention period, and whole-brain voxel-based morphometric analysis was used to detect significant cortical gray matter volume changes. We also assessed the correlation between cortical volume changes and CRT-derived neurocognitive improvements. RESULTS:The CRT group exhibited significantly greater improvements than the TAU group in verbal fluency (P = 0.012) and global cognitive scores (P = 0.049). The CRT group also exhibited significantly greater increases in right hippocampal volume than the TAU group (P < 0.001). Changes in verbal fluency scores and right hippocampal volumes were positively correlated (r = 0.53, P = 0.001). CONCLUSION:We found that CRT significantly increased right hippocampal volumes and that these enhancements were positively correlated with changes in verbal fluency scores. Our results indicate that CRT induces cognitive improvement through hippocampal plasticity. TRIAL REGISTRATION:Registration number:UMIN000026146 , 2017/02/15, retrospectively registered.
Description: 博士(医学)・甲第689号・平成30年9月26日
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
URI: http://hdl.handle.net/10564/3497
ISSN: 1471244X
Academic Degrees and number: 24601A689
Degree-granting date: 2018-09-26
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2018年度

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