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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2975

Title: Comparison between Two Separate Injections and a Single Injection of Double-dose Contrast Medium for Contrast-enhanced MR Imaging of Metastatic Brain Tumors.
Other Titles: 転移性脳腫瘍の倍量造影剤投与における、分割投与と単回投与の病変描出能の比較
Authors: Ochi, Tomoko
Taoka, Toshiaki
Matsuda, Ryosuke
Sakamoto, Masahiko
Akashi, Toshiaki
Tamamoto, Ttetsuo
Sugimoto, Tadashi
Sakaguchi, Hiroshi
Hasegawa, Masatoshi
Nakase, Hiroyuki
Kichikawa, Kimihiko
Keywords: contrast-enhanced MRI
double-dose contrast study
metastatic brain tumor
number of injections
Issue Date: 22-Dec-2014
Publisher: 日本磁気共鳴医学会(Japan Society of Magnetic Resonance in Medicine)
Citation: Magnetic resonance in medical sciences Vol.13 No.4 p.221-229
Abstract: PURPOSE: As stereotactic radiotherapy (SRT) becomes widespread, precise information including number, location, and margin of lesions is required when magnetic resonance (MR) imaging of brain metastasis is performed. We compare methods using 2 separate injections and a single injection for the administration of a double dose of contrast medium for contrastenhanced MR imaging. MATERIALS AND METHODS: We divided 40 patients with brain metastasis into 2 groups of 20 patients. Group A received 2 separate injections (0.2 + 0.2 mL/kg) of contrast medium (gadoteridol); Group B received a single injection of the same total dose (0.4 mL/kg). Group A underwent spin echo (SE) T1-weighted imaging (T1WI) and magnetization prepared rapid acquisition with gradient echo sequence (MPRAGE) after each injection, and Group B underwent the same MR studies at the same timing as Group A. We evaluated the number, signal-to-noise ratio (SNR), diameter, margin delineation, and volume of lesions and compared them between early and delayed studies by the 2 methods. RESULTS: The number of detected lesions was largest in delayed studies of MPRAGE in both groups. The SNR of the lesions was statistically lower in early studies of Group A than other studies. Delayed studies of Group B showed statistically better margin delineation than other studies on both SE-T1WI and MPRAGE studies. Diameter and enhanced volume were statistically significantly larger on delayed phase than early phase in both groups. CONCLUSION: Use of a single injection of double-dose contrast medium and longer delay time may improve margin delineation of lesions for the study of brain metastasis. Enhanced volume was larger on delayed phase, and it may influence selection of therapeutic strategy.
Description: 博士(医学)・乙第1356号・平成27年3月16日
Copyright © 2014 by Japanese Society for Magnetic Resonance in Medicine
URI: http://hdl.handle.net/10564/2975
ISSN: 13473182
DOI: http://dx.doi.org/10.2463/mrms.2013-0068
Academic Degrees and number: 24601B1356
Degree-granting date: 2015-03-16
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2014年度

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