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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.47 No.1 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/694
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| Title: | TUBULOINTERSTITIAL LESIONS IN PATIENTS WITH NON-INSULIN-DEPENDENT DIABETES MELLITUS AND DECLINE IN GLOMERULAR FILTRATION RATE |
| Authors: | Kanauchi, Masao
Iwano, Masayuki
Shiiki, Hideo
Fujii, Yoshihiro
Dohi, Kazuhiro |
| Keywords: | diabetic nephropathy
glomerular filtration rate
renal biopsy
tubulointerstitial lesion |
| Issue Date: | 29-Feb-1996 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.47 No.1 p.13-19 |
| Abstract: | To evaluate the role of tubulointerstitial lesions in diabetic nephropathy, we
studied the renal histological findings and various functional parameters in 201 patients
with non-insulin-dependent diabetes mellitus (NIDDM). The patients were divided into four
groups according to the severity of the tubulointerstitial lesions on a scale of T0 through
TⅢ. Diffuse glomerular lesions were graded by Gellman's criteria (D0 through DⅣ).
There was a weak correlation between the severity of glomerular diffuse lesions and that
of tubulointerstitial lesions ; discordance between glomerular and tubulointerstitial lesions
was presest in 37 patients (18%). Urinary excretion of β2 MG and NAG significantly
increased with the severity of tubulointerstitial lesions, whereas the creatinine clearance
decreased. Multiple regression analysis showed that glomerular and tubulbinterstitial
lesions independently contribute to the decline of the glomerular filtration rate. These
results suggest that tubulointerstitial lesions are involved in the progression of diabetic
nephropathy. |
| URI: | http://hdl.handle.net/10564/694 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.47 No.1
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Files in This Item:
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| 013-019p.TUBULOINTERSTITIAL LESIONS IN PATIENTS WITH NON-INSULIN-DEPENDENT.pdf | | 750Kb | Adobe PDF | View/Open |
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