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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.48 No.5 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/390
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| Title: | HYPOURICEMIA IN HOSPITALIZED DIABETIC PATIENTS |
| Authors: | Kanauchi, Masao
Kikawa, Tadatoshi
Nishioka, Hisayuki
Kawano, Takahiro
Fujimoto, Takashi
Shiiki, Hideo
Dohi, Kazuhiro |
| Keywords: | diabetes mellitus
hypouricemia
uric acid |
| Issue Date: | 31-Oct-1997 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.48 No.5 p.268-272 |
| Abstract: | To determine the incidepce and clinicopathological characteristics of
hypouricemia in patients with diabetes mellitus, we studied 473 consecutive hospitalized
diabetic patients. The incidence of hypouricemia, defined as a serum urate concentration
below 2.0 mg/dl, was 1.9% (9 patients). In this group (2 males, 7 females), there were no
patients receiving drugs known to reduce serum urate concentration. Two of the 9 patients
had neoplastic disease, while the others suffered from no other disorder known to affect
serum urate levels. Four patients exhibited glomerular hyperfiltration. Three of the 9
patients were studied in more detail by renal biopsy, and all had mild to moderate glomer-
ular diffuse lesions and tubulointerstitial lesions, such as interstitial fibrosis or mononuclear
cell infiltration. These findings suggest that the glomerular hyperfiltration which accom-
panies diabetic nephropathy and functional abnormality of tubular urate handling due to
tubulointerstitial involvement contribute to hypouricemia in diabetic patients. |
| URI: | http://hdl.handle.net/10564/390 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.48 No.5
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| 268-272p.HYPOURICEMIA IN HOSPITALIZED DIABETIC PATIENTS.pdf | | 438Kb | Adobe PDF | View/Open |
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