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01 奈良県立医科大学 >
012 大学院 >
0122 学位請求論文 >
01221 博士論文(医学) >
2019年度 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/3727
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タイトル: | Combination of L-Carnitine and Angiotensin-II type 1 Receptor Blocker has Beneficial Effects on Hepatic Fibrosis in a Non-Alcoholic Steatohepatitis Rat Model. |
その他のタイトル: | L-カルニチンとアンギオテンシン-II1型受容体遮断薬の組み合わせは、非アルコール性脂肪肝炎ラットモデルにおける肝線維症に有益な効果を有する |
著者: | Kubo, Takuya Kawaratani, Hideto![](/dspace/image/metalink/link_ja.gif) Sawada, Yasuhiko Fujinaga, Yukihisa Ozutsumi, Takahiro Kaya, Daisuke Tsuji, Yuki Nakanishi, Keisuke Furukawa, Masanori Kitagawa, Kou Saikawa, Soichiro Sato, Shinya Takaya, Hiroaki Kaji, Kosuke Shimozato, Naotaka Moriya, Kei Namisaki, Tadashi Akahane, Takemi Mitoro, Akira![](/dspace/image/metalink/link_ja.gif) Yoshiji, Hitoshi![](/dspace/image/metalink/link_ja.gif) |
キーワード: | Angiotensin-2 type 1 Receptor Blocker L-carnitine Nonalcoholic Steatohepatitis Hepatic Fibrosis Oxidative Stress |
発行日: | 2019年12月 |
出版者: | Biomedical Research Network+ |
引用: | Biomedical journal of scientific and technical research Vol.23 No.5 p.17787-17792 (2019 Dec) |
抄録: | Inflammation and oxidative stress contribute to the progression of nonalcoholic steatohepatitis (NASH). Hepatic fibrosis and activated hepatic stellate cells (Ac-HSCs) are attenuated by Angiotensin-II type 1 Receptor Blocker (ARB), and L-carnitine is effective for NASH by ameliorating oxidative stress, but neither agent is effective in a clinical setting. We evaluated the effect of the combination of L-carnitine and ARB on liver fibrosis using a rat NASH model. A Choline-Deficient/L-Amino Acid-defined (CDAA) diet was fed to F344 rats for 8 weeks. The rats were then divided into a control group, group receiving L-carnitine or ARB alone, and group receiving L-carnitine plus ARB. Therapeutic efficacy was assessed by evaluating liver fibrosis, liver fatty acid metabolism, and oxidative stress. ARB inhibited liver-specific tumor necrotic factor-α and LPS-binding protein, which are involved in hepatic inflammation. L-Carnitine reduced hepatic oxidative stress by rescuing hepatic sterol-regulatory elementbinding protein 1 and thiobarbituric acid reactive substances induced by the CDAA diet. Combination of L-carnitine and ARB improved liver fibrosis, with concomitant HSC suppression. Therefore, we suggest that L-carnitine and ARB are effective in suppressing liver fibrosis. Currently both drugs are in clinical use, and a combination of the two could be an effective therapy for NASH fibrosis. |
内容記述: | 博士(医学)・甲第736号・令和2年3月16日 Copyright © 2019 Hideto Kawaratani, Biomed J Sci & Tech Res. This is an openaccess article distributed under the terms of the Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/). |
URI: | http://hdl.handle.net/10564/3727 |
ISSN: | 25741241 |
DOI: | http://dx.doi.org/10.26717/BJSTR.2019.23.003969 |
学位授与番号: | 24601A736 |
学位授与年月日: | 2020-03-16 |
学位名: | 博士(医学) |
学位授与機関: | 奈良県立医科大学 |
出現コレクション: | 2019年度
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