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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2698

Title: ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score.
Other Titles: 血漿ADAMTSは肝硬変患者の予後をChild-PughスコアやMELDスコアと同様に生存率を予測できる可能性がある
Authors: Takaya, Hiroaki
Uemura, Masahito
Fujimura, Yoshihiro
Matsumoto, Masanori
Matsuyama, Tomomi
Kato, Seiji
Morioka, Chie
Ishizashi, Hiromichi
Hori, Yuji
Fujimoto, Masao
Tsujimoto, Tatsuhiro
Kawaratani, Hideto
Toyohara, Masahisa
Kurumatani, Norio
Fukui, Hiroshi
Keywords: ADAMTS13 activity
Child-Turcotte-Pugh score
liver cirrhosis
Model for End-Stage Liver Disease score
Issue Date: May-2012
Publisher: Wiley / The Japan Society of Hepatology
Citation: Hepatology research Vol.42 No.5 p.459-472
Abstract: Aim:  Decreased plasma ADAMTS13 activity (ADAMTS13:AC) results in accumulation of unusually large von Willebrand factor multimers and platelet thrombi formation. Our aim was to evaluate whether ADAMTS13:AC is a prognostic marker in patients with liver cirrhosis. Methods:  Plasma ADAMTS13:AC and its related parameters were examined in 108 cirrhotic patients. Results:  ADAMTS13:AC decreased as the severity of liver disease increased (means: controls 100%, Child A-cirrhotics 79%, Child B-cirrhotics 63%, and Child C-cirrhotics 31%). ADAMTS13:AC markedly decreased in the cirrhotics with hepatorenal syndrome, refractory ascites and hepatic encephalopathy. The cumulative survival time was the shortest (median: 4.5 months) in the cirrhotics with severe to moderate ADAMTS13:AC deficiency (<3-25%), followed by those with mild ADAMTS13:AC deficiency (25-50%), and was the longest in those with normal activity (>50%). In contrast, based on the Child-Turcotte-Pugh (CTP) score, Child C-cirrhotics had the worst survival, but the survival probabilities did not differ between Child A and B cirrhotics. Based on the Model for End-Stage Liver Disease (MELD) score, the survival was the worst for the cirrhotics in the fourth quartile, but it was not different among cirrhotics in the first three quartiles. Cox proportional-hazards regression analysis showed that ADAMTS13:AC and serum albumin were independent factors affecting the survival. Conclusions:  ADAMTS13:AC concomitantly decreases as the functional liver capacity decreases. This activity may be a useful prognostic marker that is equal or superior to the CTP score and the MELD score to predict not only the short-term prognosis but also the long-term survival of the cirrhotic patients.
Description: 博士(医学)・甲613号・平成26年3月17日
URI: http://hdl.handle.net/10564/2698
ISSN: 13866346
Academic Degrees and number: 24601A613
Degree-granting date: 2014-03-17
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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