DSpace About DSpace Software 日本語
 

GINMU >
01 奈良県立医科大学 >
011 医学部 >
0112 紀要 >
01121 Journal of Nara Medical Association >
Vol.40 No.2 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2283

Title: 加熱第Ⅷ因子濃縮製剤,Haemate Pの止血管理下に抜歯を行ったType ⅡB von Willebrand病の1例
Other Titles: TOOTH EXTRACTIONS WITH THE USE OF A HEAT-TREATED FACTOR Ⅷ CONCENTRATE (HAEMATE P) IN A PATIENT WITH TYPE ⅡB VON WILLEBRAND'S DISEASE
Authors: 田中, 一郎
新家, 興
宮田, 茂樹
西尾, 健治
吉岡, 章
福井, 弘
藤村, 吉博
山本, 成美
杉村, 正仁
Keywords: von Willebrand病2型
血液凝固第Ⅷ因子
血液製剤
抜歯
type ⅡB von Willebrand disease
heat-treated factor Ⅷ concentrate
F.Ⅷ/vWF
ristocetin cofactor
multimeric structure
exodontics
Issue Date: 30-Apr-1989
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.40 No.2 p.229-236
Abstract: A dental surgery case is described of a 12-year-old boy with type ⅡB von Willebrand's disease (vWD), suffering from toothache caused by follicular cyst with infection in the mandible. Prior to the surgery, a hemostatic effect of Haemate P was studied. After the infusion of Haemate P (84 U/kg body weight of ristocetin cofactor (Rcof.) ; 28 U/kg of factor Ⅷ activity (F. Ⅷ : C)), F. Ⅷ : C levels rose from 0.6 U/ml to 1.64 U/ml at 1 hour, 1.08 U/ml at 24 hours and 0.9 U/ml at 48 hours, respectively. The levels of Rcof. inreased from 0.24 U/ml to 2.75 U/ml at half an hour after the infusion and then gradually decreased to 0.44 U/ml at 48 hours. The levels of botrocetin cofactor (Bcof.) increased from 0.4 U/ml to 2.6 U/ml at half an hour after the infusion and then gradually decreased to the preinfusion level at 48 hours. Before the infusion, the large multimers were absent in the plasma, whereas all multimers were present in the platelets. After the infusion, the large multimers in the plasma appeared for several hours and gradually disappeared at 48 hours. Surgical procedures - an extirpation of the cyst in the mandibular bone and the extractions of 3 deciduous teeth (both sides of the second mandibular lower deciduous molars and the right upper second deciduous molar) and 1 supernumerary tooth in the maxilla ― were performed after the infusion of Haemate P (56 U/kg body weight of Rcof. ; 18 U/kg body weight of F. Ⅷ : C). Further infusions of Haemate P were given every 12 hours for 2 days and every 24 hours for the following 3 days. After each infusion of Haemate P, there was 2-3 fold increase of 3 activities of F. Ⅷ/vWF. During the course of Haemate P infusions, there was no significant side effect.
URI: http://hdl.handle.net/10564/2283
ISSN: 04695550
13450069
Appears in Collections:Vol.40 No.2

Files in This Item:

File Description SizeFormat
229-236p:加熱第Ⅷ因子濃縮製剤,Haemate_Pの止血管理下に抜歯を行ったType_ⅡB_von_Willebrand病の1例.pdf1.16 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback