食道異所性皮脂腺の2例

Abstract

Two cases of heterotopic sebaceous glands in the esophagus, found in a 71-year-old male and a 50-year-old female patient, are reported. In both cases, endoscopic examination revealed multiple yellowish plaques sized 1 to 3mm in diameter in the esophagus, which were initially interpreted as probable candida infection, xanthoma, or glycogenic acanthosis. Histological examinations of biopsy specimens showed clusters of clear cells in the squamous cell epithelium. They had pale cytoplasm with centrally located small nuclei and closely resembled sebaceous glands of the skin, and were histologically interpreted as heterotopic sebaceous glands of the esophagus. Along with recent advances in endoscopic technique, reported cases of heterotopic sebaceous glands in the esophagus are increasing. However, the histogenesis of heterotopic sebaceous glands in the esophagus has not been well established and remains to be established. The present report concerns two cases of heterotopic esophageal sebaceous glands accompanied by some immunohistochemical studies.