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01121 Journal of Nara Medical Association >
Vol.51 No.6 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/633
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Title: | 冠動脈疾患でのインスリン抵抗性の役割 : グルコースクランプ法を用いた検討 |
Other Titles: | ROLE OF INSULIN RESISTANCE IN THE DEVELOPMENT OF CORONARY ARTERY DISEASE : ASSESSMENT WITH EUGLYCEMIC HYPERINSULINEMIC CLAMP METHOD |
Authors: | 藤田, 泰三 |
Keywords: | cardiological syndrome X vasospastic angina ischemic heart disease insulin resistance euglycemic hyperinsulinemic clamp method |
Issue Date: | 31-Dec-2000 |
Publisher: | 奈良医学会 |
Citation: | Journal of Nara Medical Association Vol.51 No.6 p.426-435 |
Abstract: | Although diabetes mellitus is one of the established risk factors for coronary
artery disease (CAD), the role of insulin resistance in the development of CAD has not been
studied adequately. The purpose of this study was to evaluate the relationship between
insulin resistance and the individual types of CAD.
One hundred and twenty-seven patients with chest pain and 10 control patients without
evidence of CAD were enrolled in this study. All patients with chest pain received cardiac
catheterization, and were diagnosed as having cardiological syndrome X (n=17), vasospas-
tic angina pectoris (n=37), or CAD with coronary artery stenosis (n=73). The insulin
sensitivity was assessed by the euglycemic hyperinsulinemic clamp (EHC) method, as well
as oral glucose tolerance test (OGTT). M-value, the mean glucose infusion rate during
EHC study, was used as an index of insulin resistance. M-values of patients with either
vasospastic angina pectoris or CAD with coronary artery stenosis were significantly lower
than those of control patients, while no difference was noted between patients with car-
diological syndrome X and control patients. Insulin areas of OGTT of CAD patients with
coronary artery stenosis were significantly higher than those of control patients and
patients with vasospastic angina. The ratio of insulin area to glucose area in CAD patients
with coronary artery stenosis was significantly lower than in control patients and patients
with vasospastic angina, while no difference was noted between patients with cardiological
syndrome X and control patients.
These findings suggest that insulin resistance plays an important role in the development
of both coronary arteriosclerosis and coronary vasospasm, but not of cardiological syn-
drome X. |
URI: | http://hdl.handle.net/10564/633 |
ISSN: | 13450069 |
Appears in Collections: | Vol.51 No.6
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