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01121 Journal of Nara Medical Association >
Vol.51 No.5 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/623
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タイトル: | 胎盤絨毛外栄養膜細胞におけるHLA-G発現の消失に関する検討 |
その他のタイトル: | LACK OF HLA-G EXPRESSION IN A POPULATION OF EXTRAVILLOUS TROPHOBLAST IN NORMAL PLACENTA |
著者: | 下嶋, 典子 石谷, 昭子 羽竹, 勝彦![](/dspace/image/metalink/link_ja.gif) |
キーワード: | HLA-G extravillous trophoblast placenta preeclampsia decidua |
発行日: | 2000年10月31日 |
出版者: | 奈良医学会 |
引用: | Journal of Nara Medical Association Vol.51 No.5 p.332-342 |
抄録: | HLA-G, one of the HLA class Ib genes, shows limited expression in
placental trophoblasts, notably those at the maternal-fetal border, and is thought to be
involved in protecting the baby from maternal immune rejection. Using HLA-G mono-
clonal antibody 87 G in histochemical staining, we have investigated HLA-G expression in
first, second and third trimester placenta from a normal pregnancy, and in third trimester
placenta from preeclampsia. These studies showed that HLA-G was expressed only on
extravillous trophoblast cells (EXT) at all stages of pregnancy in normal or preeclamptic
placentas. However, a subset of EXTs that showed a complete lack of expression of HLA
-G in normal placenta was found. These EXTs expressed cytokeratin only on the cell
membrane and in cytoplasm not stained with eosin, whereas EXTs expressing HLA-G
showed cytokeratin expression on the whole cell including the cytoplasm stained with eosin.
In preeclamsia placentas, populations of EXTs lacking HLA-G expression were also found.
Interestingly, their characteristics on staining anti-cytokeratin and eosin were similar to
EXTs lacking HLA-G expression in normal placenta. Therefore, no significant differences
in HLA-G expression were found between normal and preeclamptic placentas. EXT is
classified to the intermediate differentiation stage from cytotrophoblast (CT) to
syncytiotrophoblast (ST) and EXTs can be found at various stages of differentiation at any
stage of placental development. It appears then that EXT differentiation may influence the
expression of HLA-G. The existence of EXTs lacking HLA-G expression in normal
placenta suggests that other molecules, independent of HLA-G, may function to keep a
fetus from an undesirable maternal immune response. |
URI: | http://hdl.handle.net/10564/623 |
ISSN: | 13450069 |
出現コレクション: | Vol.51 No.5
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