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01121 Journal of Nara Medical Association >
Vol.49 No.5 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/468

Title: 尿酸代謝とインスリン抵抗性との関係
Authors: 辻本, 伸宏
金内, 雅夫
尾崎, 博基
藤田, 泰三
中嶋, 民夫
土肥, 和紘
Keywords: glucose clamp technique
insulin resistance
uric acid metabolism
Issue Date: 31-Oct-1998
Publisher: 奈良医学会
Citation: Journal of Nara Medical Association Vol.49 No.5 p.349-352
Abstract: To investigate the relationship between uric acid (UA) metabolism and insulin resistance, serum creatinine concentration (Scr), serum UA concentration (SuA) and the urinary excretion of creatinine and UA were determined in 25 non-diabetic patients. Creatinine clearance (Ccr) and UA clearance/creatinine clearance ratio (CuA/Ccr) were also calculated. Insulin resistance was evaluated by the euglycemic glucose clamp tech- nique and expressed as the mean value of the glucose infusion rate (M-value). Scr and Ccr did not show any correlation with the M-value. SuA showed a significant negative correla- tion with the M-value, and CuA/Ccr showed a positive correlation with the M-value. Our data suggest that SuA is correlated with insulin resistance, and that insulin resistance may suppress the renal excretion of UA.
URI: http://hdl.handle.net/10564/468
ISSN: 13450069
Appears in Collections:Vol.49 No.5

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