尿酸代謝とインスリン抵抗性との関係

Abstract

To investigate the relationship between uric acid (UA) metabolism and insulin resistance, serum creatinine concentration (Scr), serum UA concentration (SuA) and the urinary excretion of creatinine and UA were determined in 25 non-diabetic patients. Creatinine clearance (Ccr) and UA clearance/creatinine clearance ratio (CuA/Ccr) were also calculated. Insulin resistance was evaluated by the euglycemic glucose clamp tech- nique and expressed as the mean value of the glucose infusion rate (M-value). Scr and Ccr did not show any correlation with the M-value. SuA showed a significant negative correla- tion with the M-value, and CuA/Ccr showed a positive correlation with the M-value. Our data suggest that SuA is correlated with insulin resistance, and that insulin resistance may suppress the renal excretion of UA.