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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4353

Title: Effect of Sevoflurane Anesthesia on Intraoperative Spikes, High-Frequency Oscillations, and Phase-Amplitude Coupling in MRI-Normal Hippocampus
Other Titles: MRI 正常海馬における術中棘波,高周波振動および位相振幅結合に対するセボフルラン麻酔の影響
Authors: Dahal, Riju
Tamura, Kentaro
Pan, Dong-sheng
Sasaki, Ryota
Takeshima, Yasuhiro
Matsuda, Ryosuke
Yamada, Shuichi
Nishimura, Fumihiko
Nakagawa, Ichiro
Park, Young-Soo
Hayashi, Hironobu
Kawaguchi, Masahiko
Nakase, Hiroyuki
Keywords: Hippocampus
high-frequency oscillations
HFO on spike
phase-amplitude coupling
intraoperative electrocorticography
sevoflurane
Issue Date: Oct-2023
Publisher: Lippincott Williams & Wilkins
Citation: Journal of Clinical Neurophysiology. 2023 Oct, article no.10.1097/WNP.0000000000001031
Abstract: Introduction: The purpose of this study was to determine the effect of sevoflurane anesthesia on spikes, high-frequency oscillations (HFO), and phase-amplitude coupling using a modulation index (MI) in MRI-normal hippocampus, with the aim of evaluating the utility of intraoperative electrocorticography (ioECOG) in identifying the epileptogenic hippocampus during sevoflurane administration. Methods: Eleven patients with intractable temporal lobe epilepsy with a normal hippocampus on MRI underwent extra-operative electrocorticography (eoECoG) evaluation. Patients were assigned to the Ictal (+) or Ictal (−) group depending on whether the parahippocampal gyrus was included in the seizure onset zone. IoECoG was performed under 0.5 and 1.5 minimum alveolar concentration. The rates of spikes, ripples, fast ripples (FR), ripples on spikes (RonS), fast ripples on spikes (FRonS), and MI HFO (3-4 Hz) were evaluated. Results: During the ioECoG procedure, sevoflurane administration was found to significantly increase the rate of spikes RonS, FRonS and MI HFO (3-4 Hz) in the Ictal (+) group (P < 0.01). In contrast, the Ictal (−) group exhibited a paradoxical increase in the rate of ripples and FR (P < 0.05). Conclusions: Our findings indicate that the administration of sevoflurane during ioECOG in patients with MRI-normal hippocampus can lead to a dose-dependent enhancement of epileptic biomarkers (spikes, RonS, FRonS, and MI (HFO 3-4)) in the epileptogenic hippocampus, while paradoxically increasing the rate of ripples and FR in the non-epileptogenic hippocampus. These results have significant implications for the identification of the MRI-normal hippocampus that requires surgical intervention and preservation of the non-epileptogenic hippocampus.
Description: 本文は発行元が定める公開猶予期間終了後に公開
URI: http://hdl.handle.net/10564/4353
ISSN: 0736-0258
DOI: https://doi.org/10.1097/WNP.0000000000001031
Academic Degrees and number: 24601甲第902号
Degree-granting date: 2024-03-14
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2023年度

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