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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4207

Title: Neuroprotective effects of pravastatin in cerebral venous infarction in a rat model
Other Titles: 脳皮質静脈梗塞ラットモデルを用いた脳静脈虚血におけるプラバスタチンの神経保護効果
Authors: Sato, Fumiya
Wajima, Daisuke
Takeshima, Yasuhiro
Nakagawa, Ichiro
Kim, Taekyun
Motoyama, Yasushi
Park, Young-Soo
Nakase, Hiroyuki
Keywords: Cerebral blood flow
Cerebral cortex
Cerebral ischemia
Neuronal apoptosis
Pravastatin sodium
Issue Date: Jun-2023
Publisher: Elsevier Ltd.
Citation: IBRO Neuroscience Reports. 2023 Jun, vol.14, p.202-209
Abstract: Objectives: Pravastatin sodium is reported to have multiple beneficial effects in cerebral atherosclerosis and neuronal injury; however, the preventive effects on cerebral venous ischemia are still unknown. Herein, we aimed to examine the neuroprotective effects of transoral prior administration of pravastatin sodium against cerebral cortical venous ischemia with suppression of apoptosis. Methods: Thirty 8-week-old male Wistar rats were divided equally into two study groups (n = 15 vs. n = 15); the pravastatin group was fed 1% pravastatin sodium with their usual diet for 2 weeks, while the control group only received the usual diet. Two-vein occlusion (2VO) model was applied for this study, and two adjacent cortical veins in each animal were permanently occluded photochemically with rose bengal dye. During photothrombosis, regional changes of the cerebral blood flow (CBF) in area of the venous ischemia were recorded. At 48-h after 2VO, animals were euthanized using perfusion fixation, and we histologically measured ratios of infarcted area to contralateral hemisphere, and counted Bax- and Bcl-2-positive cells in the penumbra to investigate the implications for apoptosis. Results: The ratio of infarcted area was significantly decreased in the pravastatin group compared to the control group (P < 0.01). The number of Bax-positive cells also decreased significantly in the pravastatin group (P < 0.01). In contrast, immunolabeling for Bcl-2 was essentially negative in all areas in both groups. There were also no significant differences in regional CBF changes after 2VO between the two groups (P = 0.13). Conclusions: Pre-emptive administration of pravastatin sodium mixed in the food has neuroprotective effects against cerebral cortical venous ischemia with suppression of apoptosis associated with inhibition of Bax expression but has little influence on regional CBF.
Description: 権利情報:© 2023 The Authors. Published by Elsevier Ltd on behalf of International Brain Research Organization. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
URI: http://hdl.handle.net/10564/4207
DOI: https://doi.org/10.1016/j.ibneur.2023.02.002
Academic Degrees and number: 24601甲第885号
Degree-granting date: 2023-06-23
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2023年度

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