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01121 Journal of Nara Medical Association >
Vol.72 No.4,5,6 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4034

Title: 奈良県の高齢化地域におけるボノプラザンを用いたヘリコバクター・ピロリ除菌に関する検討
Other Titles: A Study on Vonoprazan Based Helicobacter Pylori Eradication with in An Aging Community in Nara Prefecture.
Authors: 瓦谷, 英人
久保, 卓也
簗瀬, 公嗣
藤本, 優樹
中上, 純子
小林, 正尚
丸山, 直樹
前川, 勝英
松倉, 康夫
松島, 俊裕
吉治, 仁志
西尾, 健治
Keywords: Helicobacter pylori
Eradication
Elderly people
Issue Date: 30-Nov-2021
Publisher: 奈良医学会
奈良県立医科大学
Citation: Journal of Nara Medical Association Vol.72 No.4,5,6 p.29-33 (2021.11)
Abstract: Introduction: There are few reports on the efficacy and safety of vonoprazan (P-CAB) based triple eradication therapy in the elderly. In this study, we investigated the efficacy and safety of P-CAB based eradication of Helicobacter pylori (H. pylori) in non-elderly and elderly patients in our community, where the elderly population is high (41.7%). Methods: 205 patients who underwent primary and secondary eradication for H. pylori at our hospital from October 2018 to December 2020, were included in this study. Results: In primary eradication, the success rate for eradication in non-elderly and elderly patients was 96.6% (57 of 59 patients) and 88.7% (110 of 124 patients) respectively (P=0.10). The success rate for eradication in the late-elderly was 90.2% (46 of 51 patients). There was no significant difference compared with non-elderly patients (P = 0.25). The success rates for secondary eradication in non-elderly and elderly patients were 100% (7 of 7 patients) and 66.7% (10 of 15 patients). respectively, with no significant difference between the two groups (P = 0.13). The success rate for eradication in the late-elderly was low (40.0%: 2 of 5 cases). and there was significant difference compared with that in the non-elderly (P < 0.05). In the primary eradication, there was only one case of death from other diseases in the late-elderly patients during the first week after treatment. Discussion: In the elderly, the efficacy of primary eradication was similar to that for the non-elderly, and the frequency of incidental disease was low. Although the efficacy of secondary eradication was lower in the elderly, it was a safe treatment.
URI: http://hdl.handle.net/10564/4034
ISSN: 13450069
Appears in Collections:Vol.72 No.4,5,6

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