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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/4031

Title: Efficacy of autogenous bone grafts preserved in 80% ethanol solution for preventing surgical site infection after cranioplasty: A retrospective cohort study.
Other Titles: 頭蓋骨形成術後の手術部位感染予防のための80%エタノール溶液に保存した自家骨移植片の有効性。後方視的コホート研究
Authors: Kogeichi, Yohei
Motoyama, Yasushi
Takeshima, Yasuhiro
Matsuda, Ryosuke
Tamura, Kentaro
Nishimura, Fumihiko
Yamada, Shuichi
Nakagawa, Ichiro
Park, Young-Su
Fukushima, Hidetada
Nakase, Hiroyuki
Keywords: Autogenous bone graft
Decompressive craniectomy
Ethanol
Surgical site infection
Issue Date: Jun-2022
Publisher: Elsevier
Citation: Interdisciplinary neurosurgery Vol.28 Article No.101489 (2022 Jun)
Abstract: Background: Surgical site infection (SSI) is common following cranioplasty after decompressive craniectomy (DC). The aim of this study was to assess the risk of SSI following cranioplasty in terms of the preservation method of autogenous bone graft (ABG), comparing preservation in 80% ethanol versus the standard method of subcutaneous ABG preservation. Material and methods: The patients who underwent cranioplasty using ABGs after DC between 2008 and 2019 were retrospectively reviewed. SSIs were compared between patients whose ABG was preserved in 80% ethanol (group A) and those whose ABG was preserved subcutaneously (group B) using inverse probability of treatment weighting (IPTW) based on propensity scores to balance measurable confounders including elderly age, sex, expanded polytetrafluoroethylene, stroke, interval to cranioplasty, and diabetes mellitus. Results: Total number of 127 patients consisted of 56 in group A and 71 in group B. SSI after cranioplasty occurred in five patients each in groups A and B (8.9% vs. 7%, p = 0.748). IPTW analysis demonstrated that preservation in 80% ethanol was associated with a lower risk of SSI (odds ratio: 0.239, 95% confidence interval: 0.0615–0.927, p = 0.039). Conclusion: The simple and less-invasive method of preserving ABGs in 80% ethanol for cranioplasty after DC might be potentially safe from an SSI perspective.
Description: 博士(医学)・乙第1526号・令和4年3月15日
© 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND licens(https://creativecommons.org/licenses/by-nc-nd/4.0/).
URI: http://hdl.handle.net/10564/4031
ISSN: 22147519
DOI: https://doi.org/10.1016/j.inat.2022.101489
Academic Degrees and number: 24601B1526
Degree-granting date: 2022-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2021年度

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