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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3948

Title: Impact of Atrial Fibrillation on the Prognosis of Acute Decompensated Heart Failure With and Without Mitral Regurgitation.
Other Titles: 僧帽弁閉鎖不全症を伴うまたは伴わない非代償性急性心不全患者の予後に心房細動が与える影響
Authors: Hirai, Kaeko
Kawakami, Rika
Nogi, Maki
Ishihara, Satomi
Hashimoto, Yukihiro
Nakada, Yasuki
Nakagawa, Hitoshi
Ueda, Tomoya
Nishida, Taku
Onoue, Kenji
Soeda, Tsunenari
Okayama, Satoshi
Watanabe, Makoto
Okura, Hiroyuki
Saito, Yoshihiko
Keywords: Acute decompensated heart failure
Atrial fibrillation
Cardiovascular death
Heart failure-related readmission
Mitral regurgitation
Issue Date: Jul-2021
Publisher: Japanese Circulation Society
Citation: Circulation reports Vol.3 No.7 p.388-395 (2021 Jul)
Abstract: Background: Atrial fibrillation (AF) and mitral regurgitation (MR) are frequently combined in patients with heart failure (HF). However, the effect of AF on the prognosis of patients with HF and MR remains unknown. Methods and Results: We studied 867 patients (mean age 73 years; 42.7% female) with acute decompensated HF (ADHF) in the NARA-HF registry. Patients were divided into 4 groups based on the presence or absence of AF and MR at discharge. Patients with severe MR were excluded. The primary endpoint was the composite of cardiovascular (CV) death and HF-related readmission. During the median follow-up of 621 days, 398 patients (45.9%) reached the primary endpoint. In patients with MR, AF was associated with a higher incidence of the primary endpoint regardless of left ventricular function; however, in patients without MR, AF was not associated with CV events. Cox multivariate analyses showed that the incidence of CV events was significantly higher in patients with AF and MR than in patients with MR but without AF (hazard ratio 1.381, P=0.036). Similar findings were obtained in subgroup analysis of patients with AF and only mild MR. Conclusions: The present study demonstrated that AF is associated with poor prognosis in patients with ADHF with mild to moderate MR, but not in those without MR.
Description: 博士(医学)・甲第799号・令和3年9月29日
© 2021, THE JAPANESE CIRCULATION SOCIETY This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/
URI: http://hdl.handle.net/10564/3948
ISSN: 24340790
Academic Degrees and number: 24601A799
Degree-granting date: 2021-09-29
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2021年度

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