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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3917

Title: Handgrip Strength Is an Independent Predictor of Cardiovascular Outcomes in Diabetes Mellitus.
Other Titles: 握力は、糖尿病患者の心血管イベントの独立した予測因子である
Authors: Morikawa, Yoshinobu
Kawakami, Rika
Horii, Manabu
Yamamoto, Yuta
Yabuta, Matahiro
Saito, Yoshihiko
Keywords: Skeletal muscle strength
Sarcopenia
Cardiovascular disease
Issue Date: 2021
Publisher: International Heart Journal Association (インターナショナル・ハート・ジャーナル刊行会)
Citation: International heart journal Vol.62 No.1 p.50-56 (2021)
Abstract: Diabetes mellitus (DM) is associated with an increased incidence of cardiovascular events and an elevated prevalence of sarcopenia. However, the relationship between cardiovascular events and sarcopenia in patients with DM remains unclear. This study examined this relationship and investigated the predictors of cardiovascular events in this population.This study enrolled 161 patients with DM and no history of cardiovascular diseases who were admitted to our hospital for the treatment of DM between September 2012 and December 2015. Patients were divided into sarcopenia and non-sarcopenia groups, and were followed until March 2019. The primary endpoint was major adverse cardiovascular events (MACE).The mean age was 65.9 ± 1.8 years old and the mean follow-up period was 4.1 ± 0.8 years. The log-rank test indicated that MACE differed significantly between the two groups (P < 0.0001). Multivariate Cox hazard analysis identified the cardio-ankle vascular index (CAVI) and handgrip strength as independent predictors of MACE (hazard ratio [HR] = 1.18, P = 0.039; and HR = 0.70, P = 0.016, respectively).Handgrip strength is an indicator of sarcopenia in diabetic patients, and together with CAVI it was independently associated with the incidence of MACE. This suggests that the handgrip strength test might be useful in the management of patients with DM at high risk of cardiovascular outcomes.
Description: 博士(医学)・乙第1493号・令和3年3月15日
© 2021 by the International Heart Journal Association
発行元であるインターナショナル・ハート・ジャーナル刊行会の許諾を得て登録(2021年6月23日付)
ジャーナル公式サイト(J-STAGE内):https://doi.org/10.1536/ihj.20-677
URI: http://hdl.handle.net/10564/3917
ISSN: 13492365
Academic Degrees and number: 24601B1493
Degree-granting date: 2021-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2020年度

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