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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3752

Title: Plasma Renin Activity Is an Independent Prognosticator in Patients With Myocardial Infarction.
Other Titles: 血漿レニン活性値は、急性心筋梗塞患者の独立した予後予測因子である
Authors: Kamon, Daisuke
Okura, Hiroyuki
Okamura, Akihiko
Nakada, Yasuki
Hashimoto, Yukihiro
Sugawara, Yu
Ueda, Tomoya
Nishida, Taku
Onoue, Kenji
Soeda, Tsunenari
Okayama, Satoshi
Watanabe, Makoto
Kawakami, Rika
Saito, Yoshihiko
Keywords: Acute myocardial infarction
Plasma renin activity
Issue Date: 24-May-2019
Publisher: 日本循環器学会 / Japanese Circulation Society
Citation: Circulation journal Vol.83 No.6 p.1324-1329 (2019 May)
Abstract: Background: Plasma renin activity (PRA) is associated with cardiovascular events in patients with heart failure (HF), but its prognostic role in acute myocardial infarction (AMI) is unclear. Methods and Results: A total of 878 patients with information on baseline PRA on admission were selected from 1,055 AMI patients who underwent emergency coronary angiography between 2007 and 2016. The patients were divided into 2 groups according to their median PRA (2.0 ng/mL/h). The primary endpoint was major adverse cardiac events (MACE), defined as a composite of cardiovascular death and hospitalization because of HF. During follow-up (median 4.5±3.1 years), MACE occurred in 108 patients. Kaplan-Meier analysis showed that the high PRA group had significantly lower MACE-free survival than the low PRA group (log-rank P=0.0009). By multivariate analysis, high PRA was an independent predictor of MACE (hazard ratio (HR) 1.573; 95% confidence interval (CI) 1.049–2.396, P=0.0282). Similarly, among 580 patients who had not been previously treated with renin-angiotensin system inhibitors or β-blockers on admission, high PRA was an independent predictor of MACE (HR 1.732; 95% CI 1.010–3.047, P=0.0460). Conclusions: In the studied AMI patients, elevated levels of PRA were independently associated with poor prognosis.
Description: 博士(医学)・甲第745号・令和2年6月30日
URI: http://hdl.handle.net/10564/3752
ISSN: 13469843
DOI: https://doi.org/10.1253/circj.CJ-18-1195
Academic Degrees and number: 24601A745
Degree-granting date: 2020-06-30
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2020年度

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