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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3723

Title: Absolute risk of acute coronary syndrome after severe hypoglycemia: A population-based 2-year cohort study using the National Database in Japan.
Other Titles: 重症低血糖後の急性冠症候群の絶対リスク : 日本のナショナルデータベースを用いた一般集団対象の2年間のコホート研究
Authors: Nishioka, Yuichi
Okada, Sadanori
Noda, Tatsuya
Myojin, Tomoya
Kubo, Shinichiro
Ohtera, Shosuke
Kato, Genta
Kuroda, Tomohiro
Ishii, Hitoshi
Imamura, Tomoaki
Keywords: Acute coronary syndrome
Diabetes
Hypoglycemia
Issue Date: Mar-2020
Publisher: Wiley
Citation: Journal of diabetes investigation Vol.11 No.2 p.426-434 (2020 Mar)
Abstract: Aims/introduction: Although the epidemiological relationship between hypoglycemia and increased risk of acute coronary syndrome (ACS) has been well established, the time period for increased risk of ACS after a severe hypoglycemic episode remains unknown. The present study aimed to determine the ACS risk after a severe hypoglycemic episode. Materials and methods: We carried out a retrospective population-based cohort study based on national claims data in Japan. We retrieved data of diabetes patients aged ≥35 years collected from April 2014 to March 2016. The absolute risk of ACS was defined as the occurrence of an emergency percutaneous coronary intervention after a severe hypoglycemic episode. Results: In total, data of 7,909,626 patients were included in the analysis. The absolute risk of ACS was 2.9 out of 1,000 person-years in all patients. ACS risk in patients with severe hypoglycemic episodes was 3.0 out of 1,000 person-years. Severe hypoglycemic episodes increased the absolute risk of ACS in patients aged ≥70 years, but not in patients aged <70 years. The absolute risk of ACS was 10.6 out of 1,000 person-years within 10 days of a severe hypoglycemic episode. There was a significant trend between shorter duration after an episode and higher ACS risk. Conclusions: Severe hypoglycemia was associated with an increased risk of ACS in elderly diabetes patients. ACS risk increased with a shorter period after a severe hypoglycemic episode, suggesting that severe hypoglycemia leads to an increased risk of ACS in diabetes patients. These findings show that it is important to avoid severe hypoglycemia while treating diabetes, particularly in elderly patients.
Description: 博士(医学)・甲第732号・令和2年3月16日
© 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License(https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
URI: http://hdl.handle.net/10564/3723
ISSN: 20401116
Academic Degrees and number: 24601A732
Degree-granting date: 2020-03-16
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2019年度

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01甲732本文の要旨.pdf甲732本文の要旨1.86 MBAdobe PDFView/Open
02甲732審査要旨.pdf甲732審査要旨3.22 MBAdobe PDFView/Open
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04甲732Table S1.pdf甲732Table S1724.95 kBAdobe PDFView/Open
05甲732Table S2.pdf甲732Table S2468.53 kBAdobe PDFView/Open

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