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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3549

Title: Alteration of β-Adrenoceptor Signaling in Left Ventricle of Acute Phase Takotsubo Syndrome: a Human Study.
Other Titles: 急性期たこつぼ症候群症例の心内膜心筋生検を用いた左室心筋細胞におけるβ-アドレナリン受容体シグナル動態の検討
Authors: Nakano, Tomoya
Onoue, Kenji
Nakada, Yasuki
Nakagawa, Hitoshi
Kumazawa, Takuya
Ueda, Tomoya
Nishida, Taku
Soeda, Tsunenari
Okayama, Satoshi
Watanabe, Makoto
Kawata, Hiroyuki
Kawakami, Rika
Horii, Manabu
Okura, Hiroyuki
Uemura, Shiro
Hatakeyama, Kinta
Sakaguchi, Yasuhiro
Saito, Yoshihiko
Issue Date: 24-Aug-2018
Publisher: Springer Nature Publishing AG
Citation: Scientific reports Vol.8 No.1 Article No.12731 (2018 Aug)
Abstract: Accumulating evidence indicates alteration of the β-adrenoceptor (AR), such as desensitization and subtype switching of its coupling G protein, plays a role in the protection against catecholamine toxicity in heart failure. However, in human takotsubo syndrome (TTS), which is associated with a surge of circulating catecholamine in the acute phase, there is no histologic evidence of β-AR alteration. The purpose of this study was to investigate the involvement of alteration of β-AR signaling in the mechanism of TTS development. Left ventricular (LV) biopsied samples from 26 patients with TTS, 19 with normal LV function, and 26 with dilated cardiomyopathy (DCM) were studied. G protein-coupled receptor kinase 2 (GRK2) and β-arrestin2, which initiate the alteration of β-AR signaling, were more abundantly expressed in the myocardium in acute-phase TTS than in those of DCM and normal control as indicated by immunohistochemistry. The percentage of cardiomyocytes that showed positive membrane staining for GRK2 and β-arrestin2 was also significantly higher in acute-phase TTS. Sequential biopsies in the recovery-phase for two patients with TTS revealed that membrane expression of GRK2 and β-arrestin2 faded over time. This study provided the first histologic evidence of the involvement of alteration of β-ARs in the development of TTS.
Description: 博士(医学)・甲第701号・平成31年3月15日
© The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
© 2018 Springer Nature Publishing AG
URI: http://hdl.handle.net/10564/3549
ISSN: 20452322
Academic Degrees and number: 24601A701
Degree-granting date: 2019-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2018年度

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