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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3502

Title: Influence of Underlying Diseases and Age on the Association between Obesity and All-Cause Mortality in Post-Middle Age.
Other Titles: 肥満と全原因死亡率との関連に基礎疾患と年齢が及ぼす影響
Authors: Yoshimoto, Kazuki
Noda, Tatsuya
Imamura, Tomoaki
Keywords: Underlying Diseases
All-Cause Mortality
Post-Middle Age
Issue Date: 11-Sep-2018
Publisher: Scientific Research Publishing Inc.
Citation: Health Vol.10 No.9 p.1171-1184 (2018 Sep)
Abstract: Background: Studies on the association between obesity and all-cause mortality have found that the degree of obesity is directly proportional to all-cause mortality. In contrast, there have been studies indicating that obese people with underlying diseases have a higher survival rate. We hypothesized that age and underlying diseases lead to such contrasting results. Therefore, we conducted a study to clarify the influence of post-middle age obesity and underlying diseases on all-cause mortality. Methods: This study used data from longitudinal studies in the United States, which conducted follow-up for 19 years on 33,708 participants in different age groups: ≥45, 45 - 64, and ≥65 years. Hazard ratio (HR) was determined using the Cox proportional hazards model to analyze a group consisting of all participants, a group of those with underlying diseases, and a group of those without underlying diseases, considering age, gender, education history, marital status, household income, smoking history, and BMI category as covariates. Results: In the group aged ≥65 without underlying diseases, HR was almost 1 in those with BMI 25 - <30, 30 - <35, and BMI > 35 kg/m2. Further, HR was higher in the 45 - 64 age group without underlying diseases if BMI was >35 kg/m2. However, HR was approximately 1 in the ≥65 age group. Conclusions: The study revealed that among individuals aged ≥65 years without underlying diseases, there was no association between obesity and all-cause mortality. Among individuals without underlying diseases, HR was higher in the 45 - 64 age group with BMI > 35 kg/m2 but was approximately 1 among those aged ≥65 years. Therefore, an interaction based on age was detected. These findings may lead to recommendations regarding the need to modify the advice and education provided to obese individuals in different age groups.
Description: 博士(医学)・甲第691号・平成30年11月30日
Copyright © 2018 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/
URI: http://hdl.handle.net/10564/3502
ISSN: 19494998
Academic Degrees and number: 24601A691
Degree-granting date: 2018-11-30
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2018年度

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