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01121 Journal of Nara Medical Association >
Vol.69 No.1,2,3 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3496

Title: Is the linear-quadratic model appropriate for stereotactic irradiation of metastatic brain tumors?
Other Titles: L-Qモデルは転移性脳腫瘍の定位放射線照射に適用可能か?
Authors: Yoshimine, Tadashi
Fujitani, Nobumasa
Ikeguchi, Toshitaka
Iwami, Hiroshi
Matsuda, Ryosuke
Tamamoto, Tetsuro
Morimoto, Yoko
Hasegawa, Masatoshi
Keywords: LQ model
stereotactic irradiation
Issue Date: 30-Jun-2018
Publisher: 奈良医学会
Citation: Journal of Nara Medical Association Vol.69 No.1,2,3 p.9-15 (2018.6)
Abstract: The biologically effective dose (BED) based on the linear-quadratic (LQ) model has been commonly used to evaluate the dose-effect relationships among the different fractionation schedules, but whether the LQ model is appropriate for hypofractionated (HF) high-dose stereotactic irradiation (STI) is uncertain. The validity of the model at high doses per fraction has been critically examined. In this study, STI of metastatic brain tumors was evaluated to suggest the applicability of the LQ model to HF high-dose radiotherapy. No significant difference was found between stereotactic radiosurgery (SRS) and HF stereotactic radiotherapy (SRT) in the analyses of 151 tumors. Furthermore, no significant differences were found among SRS, HF-SRT, and non-HF SRT in 117 metastatic lung adenocarcinomas. The results of this study suggest that BED calculation is a reasonable approach for careful dose-effect evaluation based on the LQ model for HF high-dose radiotherapy for metastatic brain tumors, especially lung adenocarcinomas.
Description: 博士(医学)・甲第688号・平成30年9月26日
URI: http://hdl.handle.net/10564/3496
ISSN: 13450069
Academic Degrees and number: 24601A688
Degree-granting date: 2018-09-26
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:Vol.69 No.1,2,3

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