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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3380

Title: Clinical and immunologic features of recurrent herpes zoster (HZ).
Other Titles: 再発性帯状疱疹の臨床的、免疫学的特徴
Authors: Nakamura, Yuki
Miyagawa, Fumi
Okazaki, Aiko
Okuno, Yoshinobu
Mori, Yasuko
Iso, Hiroyasu
Yamanishi, Koichi
Asada, Hideo
Shozu Herpes Zoster Study Group
Keywords: cell-mediated immunity
humoral immunity
large-scale community-based prospective cohort study
primary herpes zoster
recurrent herpes zoster
varicella-zoster virus
Issue Date: Nov-2016
Publisher: Elsevier
Citation: Journal of the American Academy of Dermatology Vol.75 No.5 p.950-956.e1 (2016 Nov)
Abstract: BACKGROUND: Recurrent herpes zoster (HZ) is thought to be rare, but there have been few large-scale studies of recurrent HZ. OBJECTIVE: We conducted a large-scale prospective cohort study to characterize recurrent HZ. METHODS: We examined 12,522 participants aged 50 years or older in Shozu County and followed them up for 3 years. We compared the incidence of HZ and postherpetic neuralgia, severity of skin lesions and acute pain, cell-mediated immunity, and varicella-zoster virus-specific antibody titer between primary and recurrent HZ. RESULTS: A total of 401 participants developed HZ: 341 with primary HZ and 60 with recurrent HZ. Skin lesions and acute pain were significantly milder and the incidence of postherpetic neuralgia was lower in patients aged 50 to 79 years with recurrent HZ than in those with primary HZ. Varicella-zoster virus skin test induced a stronger reaction in patients aged 50 to 79 years with recurrent HZ than in those with primary HZ. LIMITATIONS: Information on previous HZ episodes was self-reported by participants, so it could not be confirmed that they actually had a history of HZ. CONCLUSION: Recurrent HZ was associated with milder clinical symptoms than primary HZ, probably because of stronger varicella-zoster virus-specific cell-mediated immunity in the patients with recurrence.
Description: 博士(医学)・甲第674号・平成29年9月27日
Copyright © 2016 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/10564/3380
ISSN: 01909622
DOI: https://doi.org/10.1016/j.jaad.2016.05.037
Academic Degrees and number: 24601A674
Degree-granting date: 2017-09-27
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2017年度

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