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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3311

Title: Frontal lobe function in elderly patients with Alzheimer's disease and caregiver burden.
Other Titles: アルツハイマー型認知症患者における前頭葉機能と介護負担の関係
Authors: Hashimoto, Akiko
Matsuoka, Kiwamu
Yasuno, Fumihiko
Takahashi, Masato
Iida, Junzo
Jikumaru, Kiyoko
Kishimoto, Toshifumi
Keywords: Alzheimer's disease
caregiver burden
frontal lobe function
Issue Date: 2017
Publisher: John Wiley & Sons, Inc
Citation: Psychogeriatrics [Epub ahead of print] (2017 Jan 28)
Abstract: AIM: Understanding of the relationship between caregiver burden and the degree of behavioural deficits in patients with Alzheimer's disease (AD) is relatively limited. Therefore, it is worthwhile to examine the correlations between the various relevant factors to improve the efficacy of care for patients with AD. The aim of this study was to investigate the specific contributions of frontal lobe dysfunction in AD patients to caregiver burden, while controlling for other predictor variables. METHODS: Participants included 30 pairs of caregivers and patients with AD. The Zarit Burden Interview and Frontal Assessment Battery were used to measure the caregiver burden and patients' frontal lobe function, respectively. To investigate the effects of frontal lobe dysfunction on caregiver burden, hierarchical regression equations with steps incorporating additional predictor variables were fitted. We also performed a correlation analysis between the individual subdomains of the Zarit Burden Interview and the predictor variables. RESULTS: Our study suggests that the degree of frontal lobe dysfunction in AD patients predicts their caregiver burden, when other factors of daily functional limitations and neuropsychiatric symptoms are controlled. Daily functional limitations and neuropsychiatric symptoms affected caregivers' psychosocial burden, whereas frontal lobe dysfunction affected caregivers' burden due to the increase in the dependency of the patients. CONCLUSION: Our findings indicate that to ameliorate the disabilities of patients and reduce caregiver burden, there is a need for interventions that focus on psychosocial burdens, as shown in previous studies, as well as on excessive dependency due to frontal lobe dysfunction.
Description: 博士(医学)・甲第661号・平成29年3月15日
© 2017 Japanese Psychogeriatric Society
This is the pre-peer reviewed version of the following article: http://dx.doi.org/10.1111/psyg.12231, which has been published in final form at http://dx.doi.org/10.1111/psyg.12231. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
URI: http://hdl.handle.net/10564/3311
ISSN: 13463500
Academic Degrees and number: 24601A661
Degree-granting date: 2017-03-15
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2016年度

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