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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/3103

Title: Osteogenic Matrix Cell Sheets Facilitate Osteogenesis in Irradiated Rat Bone.
Other Titles: ラットにおいて骨形成細胞シートは放射線照射骨の骨形成能を促進させる
Authors: Uchihara, Yoshinobu
Akahane, Manabu
Shimizu, Takamasa
Ueha, Tomoyuki
Morita, Yusuke
Nakasaki, Shintaro
Kura, Tomohiko
Tohma, Yasuaki
Kido, Akira
Kawate, Kenji
Tanaka, Yasuhito
Issue Date: 2015
Publisher: Hindawi Pub. Co.
Citation: BioMed research international Vol.2015 ID:629168
Abstract: Reconstruction of large bone defects after resection of malignant musculoskeletal tumors is a significant challenge in orthopedic surgery. Extracorporeal autogenous irradiated bone grafting is a treatment option for bone reconstruction. However, nonunion often occurs because the osteogenic capacity is lost by irradiation. In the present study, we established an autogenous irradiated bone graft model in the rat femur to assess whether osteogenic matrix cell sheets improve osteogenesis of the irradiated bone. Osteogenic matrix cell sheets were prepared from bone marrow-derived stromal cells and co-transplanted with irradiated bone. X-ray images at 4 weeks after transplantation showed bridging callus formation around the irradiated bone. Micro-computed tomography images at 12 weeks postoperatively showed abundant callus formation in the whole circumference of the irradiated bone. Histology showed bone union between the irradiated bone and host femur. Mechanical testing showed that the failure force at the irradiated bone site was significantly higher than in the control group. Our study indicates that osteogenic matrix cell sheet transplantation might be a powerful method to facilitate osteogenesis in irradiated bones, which may become a treatment option for reconstruction of bone defects after resection of malignant musculoskeletal tumors.
Description: 博士(医学)・甲第642号・平成25年11月27日
Copyright © 2015 Yoshinobu Uchihara et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/10564/3103
ISSN: 23146141
Academic Degrees and number: 24601A642
Degree-granting date: 2015-11-27
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2015年度

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