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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2782

Title: Carnitine-induced senescence in glioblastoma cells.
Other Titles: 神経膠芽腫細胞におけるカルニチンによるセネッセンスの誘導
Authors: Yamada, Shuichi
Matsuda, Ryosuke
Nishimura, Fumihiko
Nakagawa, Ichiro
Motoyama, Yasushi
Park, Young-Su
Nakamura, Mitsutoshi
Nakase, Hiroyuki
Ouji, Yukiteru
Yoshikawa, Masahide
Keywords: carnitine
glioblastoma
senescence
Issue Date: Jul-2012
Publisher: Spandidos Publications
Citation: Experimental and therapeutic medicine Vol.4 No.1 p.21-25
Abstract: Carnitine is essential for lipid metabolism in cells and is known to possess antioxidant properties. Previous reports have suggested that antioxidants are able to induce senescence in glioblastoma cells, consequently, in the present study, we investigated the effect of carnitine on glioblastoma cells. Under conditions of hyponutrition (undernutrition), the proliferation of glioblastoma cells was attenuated and the level of intracellular carnitine was increased. Glioblastoma cell proliferation was also attenuated in cultures that were supplemented with exogenous carnitine, where the induction of senescence was detected by senescence-associated β-gal (SA-β-gal) staining. However, there was no evidence of the induction of apoptosis. These effects were not detected when cells were cultured with carnitine plus an inhibitor of p38 mitogen-activated protein kinase (MAPK). It, therefore, appears that carnitine has antioxidant actions in normal cells but induces senescence, which may be regarded as an opposite phenomenon, in glioblastoma cells. Senescence has been reported in cells exposed to temozolomide, which is a standard drug used for the treatment of glioblastoma. Carnitine could, therefore, represent an attractive alternative therapy for glioblastoma.
Description: 博士(医学)・乙第1302号・平成24年11月27日
Copyright © Spandidos Publications 2012
URI: http://hdl.handle.net/10564/2782
ISSN: 17920981
Appears in Collections:2012年度

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