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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2759

Title: Brain structural changes and neuropsychological impairments in male polydipsic schizophrenia.
Other Titles: 多飲水統合失調症男性患者における脳構造変化と神経心理学的障害
Authors: Nagashima, Tomohisa
Inoue, Makoto
Kitamura, Soichiro
Kiuchi, Kuniaki
Kosaka, Jun
Okada, Koji
Kishimoto, Naoko
Taoka, Toshiaki
Kichikawa, Kimihiko
Kishimoto, Toshifumi
Keywords: Schizophrenia
Polydipsia
Volumetry
MRI
Neuropsychological impairment
Brief assessment of cognition in schizophrenia
Issue Date: Nov-2012
Publisher: BioMed Central
Citation: BMC Psychiatry Vol.12 p.210
Abstract: BACKGROUND:Polydipsia frequently occurs in schizophrenia patients. The excessive water loading in polydipsia occasionally induces a hyponatremic state and leads to water intoxication. Whether polydipsia in schizophrenic patients correlates with neuropsychological impairments or structural brain changes is not clear and remains controversial. METHODS:Eight polydipsic schizophrenia patients, eight nonpolydipsic schizophrenia patients, and eight healthy controls were recruited. All subjects underwent magnetic resonance imaging (MRI) and neuropsychological testing. Structural abnormalities were analyzed using a voxel-based morphometry (VBM) approach, and patients' neuropsychological function was assessed using the Brief Assessment of Cognition in Schizophrenia, Japanese version (BACS-J). RESULTS:No significant differences were found between the two patient groups with respect to the clinical characteristics. Compared with healthy controls, polydipsic patients showed widespread brain volume reduction and neuropsychological impairment. Furthermore, the left insula was significantly reduced in polydipsic patients compared with nonpolydipsic patients. These nonpolydipsic patients performed intermediate to the other two groups in the neuropsychological function test. CONCLUSIONS:It is possible that polydipsia or the secondary hyponatremia might induce left insula volume reduction. Furthermore, this structural brain change may indirectly induce more severe neuropsychological impairments in polydipsic patients. Thus, we suggest that insula abnormalities might contribute to the pathophysiology of polydipsic patients.
Description: 博士(医学)・甲第595号・平成25年3月15日
© 2012 BioMed Central Ltd
URI: http://hdl.handle.net/10564/2759
ISSN: 1471244X
Appears in Collections:2012年度

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