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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2710

Title: Individuals' half-lives for 2,3,4,7,8-penta-chlorodibenzofuran (PeCDF) in blood: correlation with clinical manifestations and laboratory results in subjects with Yusho.
Other Titles: 血中の2,3,4,7,8-五塩化ダイベンゾフラン(PeCDF)の個人の半減期:油症患者における臨床症状並びに検診結果との関係
Authors: Matsumoto, Shinya
Akahane, Manabu
Kanagawa, Yoshiyuki
Kajiwara, Jumboku
Todaka, Takashi
Yasukawa, Fumiko
Uchi, Hiroshi
Furue, Masutaka
Imamura, Tomoaki
Keywords: Dibenzofuran
Cedar pollen allergy
Red blood cell
Issue Date: Aug-2013
Publisher: Elsevier Science Ltd
Citation: Chemosphere Vol.92 No.7 p.772-777
Abstract: BACKGROUND: In 1968, many people developed dioxin poisoning (Yusho) in Japan. Ingestion of 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-PeCDF) was considered to be the cause of this poisoning. Although some patients had high concentrations of 2,3,4,7,8-PeCDF in their blood, individuals' half-lives of 2,3,4,7,8-PeCDF were long. OBJECTIVES: To evaluate the relationship between clinical and laboratory parameters and the individual half-life of 2,3,4,7,8-PeCDF in blood. METHODS: Clinical and laboratory data were collected during annual check-ups from 2001 to 2008. We enrolled 71 patients, who were measured more than 3 times, and who had 2,3,4,7,8-PeCDF concentrations in blood >50pgg(-1) lipid. The half-life of 2,3,4,7,8-PeCDF for each patient was estimated using linear regression. Moreover, relationships between clinical and laboratory parameters and individual half-life were investigated by linear regression. RESULTS: A shortened individual half-life for 2,3,4,7,8-PeCDF was significantly correlated with an increased red blood cell count, increased viscous secretions from the meibomian glands, existing black comedones, and severe cedar pollen allergy. CONCLUSIONS: Symptoms that accelerate excretion of lipids from the body, such as viscous secretions from the meibomian glands, may lead to a shorter half-life of 2,3,4,7,8-PeCDF. Red blood cells are related to the half-life of 2,3,4,7,8-PeCDF. However, further studies are required to investigate the excretory mechanism of 2,3,4,7,8-PeCDF.
Description: 博士(医学)・乙1325号・平成26年3月17日
URI: http://hdl.handle.net/10564/2710
ISSN: 00456535
Academic Degrees and number: 24601B1325
Degree-granting date: 2014-03-17
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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