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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/2676

Title: Post-ischemic administration of vascular endothelial growth factor inhibitor in a rat model of cerebral venous infarction.
Other Titles: ラット脳静脈モデルにおける血管内皮増殖因子桔抗薬の虚血後投与
Authors: Miyake, Hitoshi
Nakagawa, Ichiro
Takeshima, Yasuhiro
Nishimura, Fumihiko
Park, Young-Su
Nakamura, Mitsutoshi
Nakase, Hiroyuki
Keywords: cerebral venous infarction
vascular endothelial growth factor
brain edema
Issue Date: 2013
Publisher: 日本脳神経外科学会
Citation: Neurologia medico-chirurgica Vol.53 No.3 p.135-140
Abstract: Cerebral venous ischemia can result in severe brain edema. Inhibition of vascular endothelial growth factor (VEGF) activity by a neutralizing antibody can completely block the hypoxia-induced increase in vascular permeability. VEGF, which induces angiogenesis, also acts as a vascular permeability (VP) factor. We previously showed that inhibition of VEGF attenuates VP and reduces cerebral venous infarction (CVI) in the acute stage. The present study investigated the therapeutic time window during which inhibition of VEGF can reduce CVI in a rat two-vein occlusion (2-VO) model. A 2-VO model was created by photochemically occluding two adjacent cortical veins. Male Wistar rats (n = 42) were assigned to one of four groups: Group 1 was treated with a VEGF antagonist at 24 hours after 2-VO (n = 11); Group 2 was treated with phosphate-buffered solution (PBS) at 24 hours after 2-VO (n = 11); Group 3 was treated with a VEGF antagonist at 48 hours after 2-VO (n = 10); and Group 4 was treated with PBS at 48 hours after 2-VO (n = 10). The developing ischemic infarct was evaluated histologically at 7 days after 2-VO. CVI areas were significantly smaller in Group 1 than in Groups 2, 3, and 4 (p <0.05) but were similar when comparing Groups 3 and 4. Anti-VEGF therapy was effective in reducing CVI in rats if started within 24 hours after 2-VO.
Description: 博士(医学)・乙第1321号・平成25年11月27日
Copyright © 日本脳神経外科学会 | The Japan Neurosurgical Society / 学会誌名(Neurologia medico-chirurgica)とJ-STAGEからの出典である
URI: http://hdl.handle.net/10564/2676
ISSN: 04708105
Academic Degrees and number: 24601B1321
Degree-granting date: 2013-11-27
Degree name: 博士(医学)
Degree-granting institutions: 奈良県立医科大学
Appears in Collections:2013年度

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