全胞状奇胎胎盤におけるHLA-E,-F,-Gの発現に関する検討

Abstract

In this study, we focused on HLA-E, -F and -G expression on placental trophoblasts in complete hydatidiform mole comparing these cells with early normal pregnancy. Five normal placentas at 7-9 weeks and 4 complete hydatidiform moles were tested for the expression of HLA-E, -F and -G by immunohistochemical staining using anti HLA-E, -F and -G antibodies (3D12, 3D11, and 87G). The expression of HLA-E in hydatidiform mole was slightly stronger than in early normal placentas, while the expression of HLA-F was significantly stronger, with no substantial difference in HLA-G expression between hydatidiform mole and normal placenta. The meaning of the increased expression of HLA-F is not yet clear, since the function of HLA-F is unknown at this point. However, these results are suggestive of the possibility that increased HLA-F expression is influencing the growth and invasion of the tissue of the hydatidiform mole. This idea is based on our previous findings that certain types of undifferentiated cancer tissues expressed HLA-F. Further, it is suggested that increased levels of HLA-E expression may enhance the suppression of cytolytic activity of NK cell and protect the hydatidiform mole.