DSpace About DSpace Software 日本語
 

GINMU >
01 奈良県立医科大学 >
011 医学部 >
0112 紀要 >
01121 Journal of Nara Medical Association >
Vol.57 No.4-5 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/262

Title: 全胞状奇胎胎盤におけるHLA-E,-F,-Gの発現に関する検討
Other Titles: DETECTION OF HLA-E,-F,-G EXPRESSION ON PLACENTAL TROPHOBLASTS IN COMPLETE HYDATIDIFORM MOLE
Authors: 正武, 孝規
下嶋, 典子
中西, 真理
大村, 素子
粕田, 承吾
石谷, 昭子
羽竹, 勝彦
徳井, 宏
林, 行夫
Keywords: HLA-E
HLA-F
HLA-G
complete hydatidiforrn mole
extravillous trophoblasts (EVTs)
Issue Date: 31-Oct-2006
Publisher: 奈良医学会
奈良県立医科大学
Citation: Journal of Nara Medical Association Vol.57 No.4-5 p.123-129
Abstract: In this study, we focused on HLA-E, -F and -G expression on placental trophoblasts in complete hydatidiform mole comparing these cells with early normal pregnancy. Five normal placentas at 7-9 weeks and 4 complete hydatidiform moles were tested for the expression of HLA-E, -F and -G by immunohistochemical staining using anti HLA-E, -F and -G antibodies (3D12, 3D11, and 87G). The expression of HLA-E in hydatidiform mole was slightly stronger than in early normal placentas, while the expression of HLA-F was significantly stronger, with no substantial difference in HLA-G expression between hydatidiform mole and normal placenta. The meaning of the increased expression of HLA-F is not yet clear, since the function of HLA-F is unknown at this point. However, these results are suggestive of the possibility that increased HLA-F expression is influencing the growth and invasion of the tissue of the hydatidiform mole. This idea is based on our previous findings that certain types of undifferentiated cancer tissues expressed HLA-F. Further, it is suggested that increased levels of HLA-E expression may enhance the suppression of cytolytic activity of NK cell and protect the hydatidiform mole.
URI: http://hdl.handle.net/10564/262
ISSN: 13450069
Appears in Collections:Vol.57 No.4-5

Files in This Item:

File Description SizeFormat
123-129p.全胞状奇胎胎盤におけるHLA-E,-F,-Gの発現に関する検討.pdf3.08 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback