5-FU/CDDP療法中に多発脳梗塞を発症した進行胃癌の一例

Abstract

A 64-year-old man visited our hospital with a chief complaint of appetite loss and epigastralgia. Upper GI series and an endoscopic examination revealed type 3 carcinoma on the upper third. Abdominal CT scan showed enlargement of the paraaortic lymph nodes that had invaded the pancreas. Preoperative diagnosis was cStage Ⅳ gastric cancer, and we considered a curative operation impossible. Therefore, chemotherapy with a combination therapy of 5-fluorouracil (5-FU) and low-dose cisplatin (CDDP) was planned. After 19 days of administration, the patient without vascular risk factors suddenly exhibited diplopia and left-member weakness. Brain CT showed a low- density area at the occipital lobe. Though we diagnosed cerebral infarction and treated with anti-thrombus therapy, he died of multiple cerebral infarction on day 12 of the treatrnent.