奈良県立医科大学附属病院輸血部における過去10年間の赤血球不規則性抗体の検出統計

Abstract

Anti-red blood cell (RBC) irregular antibody is a “hallmark" of antibodies which are produced by stimulating antigens "out-of-the-law" of Landsteiner. Experience has indicated that antibodies that are reactive only at temperatures below 37℃ are clinically benign except for certain clinical conditions such as hypothermic cardiac surgery. During the past 10 years, we have screened a total of 29,408 blood samples and found that 557 cases (1.9%) have irregular antibodies to specific antigen on RBC that are reactive at either 37℃ or below 37℃, or at both. Both the screening and identification tests for antibody detection were performed using a commercial kit (Ortho Co.) and by the methods of saline, bromelin, albumin, and Coombs. Prevalence of irregular antibody was in the following order ; anti-Lewis 39.3%, anti-P₁ 31.8%, anti-E (with complex form) 12.8%, anti-D 2.5%, and others 13.6%. Clinical course and laboratory findings of two rare cases having anti-Diª or anti-Jrª are also described on this specific occasion.