膀胱癌における免疫学的パラメータの変動の検討

Abstract

The present investigation was conducted to examine the relationship between immunological parameters and prognosis in cases of invasive bladder cancer. A total of 48 patients were entered into this study. They underwent invasive treatment which may greatly affect host immunity (e. g. radical surgery, radiation therapy and cisplatin based combination chemotherapy). Immunological parameters include peripheral lymphocyte count, IgG, IgA, IgM, C3, C4, IgG-FcR(+)T cell, OKT4/8 ratio and Su-PS skin test ; these were examined before and 1, 3 and 6 months after treatment. Peripheral lymphocyte count in the BRM untreated group showed a significant difference between before and after chemotherapy or surgery. Su-PS skin reaction in the BRM untreated group also showed a significant difference between before and after surgery. There were significant differences in OKT 4/8 ratios between cancer death group and no evidence of disease group. These results suggest that OKT4/8 ratio may reflect the prognosis of patients with invasive bladder cancer. In addition, lymphocyte count and Su-PS skin reaction may be parameters of indication for BRM treatment.