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http://hdl.handle.net/10564/912
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| Title: | Restraint Plus Water-immersion Stress (RWIS)-induced Stomach Ulcers in Mice are Depressed by a Conditioning Heat Treatment |
| Authors: | Yamagata, Rikio
Takahashi, Akihisa
Su, Xiaoming
Morimoto, Tomoko
Ohnishi, Takeo |
| Keywords: | heat stress
restraint plus water-immersion stress (RWIS)
stomach ulcer
apoptosis
adaptive response |
| Issue Date: | 2006 |
| Publisher: | 日本ハイパーサーミア学会 |
| Citation: | Thermal Medicine Vol. 25 (2009) , No. 3 pp.81-87 |
| Abstract: | A conditioning mild heat treatment can depress subsequent severe heat-induced biological damage by inducing thermal tolerance. In the work described here, the effect of a conditioning mild heat exposure at 37°C was examined on the formation of gastric mucosa damage induced by a restraint plus water-immersion stress (RWIS) treatment in mice. RWIS treatments induced stomach ulcers in about 42% of the control animals, but a mild conditioning heat treatment at 37°C was found to depress the appearance of ulcers, and only about 9% of the pre-exposed animals developed ulcers. In addition, RWIS treatment induced an apoptosis rate in the stomach of about 13%, but a conditioning mild heat treatment depressed the apoptotic rate to about 8%. Since the heat shock protein (HSP) inducer geranylgeranylacetone (GGA) also efficiently depressed stomach ulcer incidence rates, it is suggested that gastric mucosa damage may be depressed by HSPs induced by a mild conditioning heat treatment through the depression of apoptosis. |
| Description: | 著作権者：日本ハイパーサーミア学会
日本ハイパーサーミア学会及び著作者の許諾を得て登録 |
| URI: | http://hdl.handle.net/10564/912 |
| ISSN: | 09112529 |
| Appears in Collections: | 011 医学科
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Files in This Item:
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| Thermal Medicine 2009 25(3) p.81-87（掲載可）.pdf | | 249Kb | Adobe PDF | View/Open |
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