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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/910

Title: Heat-induced Signal Transduction Pathways Leading to Cell Death and Cell Survival in Cancer Cells
Authors: Kajihara, Atsuhisa
Takahashi, Akihisa
Ohnishi, Takeo
Keywords: signal transduction
cell death
cell survival
protein microarray
Issue Date: 2006
Publisher: 日本ハイパーサーミア学会
Citation: Thermal Medicine Vol. 25 (2009) , No. 1 pp.1-11
Abstract: In recent years, cancer therapy research has focused on molecular targets. For efficient hyperthermic cancer therapy, potential targets of interest are molecules which respond to heat and selectively activate signal transduction factors which can inhibit cancer cell proliferation. Signal transduction pathways affected by heat include p53 mediated pathways, JNK (Jun N-terminal kinase) mediated pathways, Akt (protein kinase B) mediated pathways, NBS1 (Nijimegen breakage syndrome 1) mediated pathways, classic MAP (mitogen activated protein) kinase mediated pathways, and p38 MAP kinase mediated pathways. Events such as cell death, cell survival, cell proliferation, and/or cell cycle arrest can be affected by these pathways. To learn more about heat-induced gene and protein expression, cDNA arrays and protein microarrays were used to study cellular responses to heat. This paper briefly reviews interactions of pro- and anti-apoptotic genes and proteins which are induced by heat shock and are components of signal transduction pathways.
Description: 著作権者:日本ハイパーサーミア学会
URI: http://hdl.handle.net/10564/910
ISSN: 09112529
Appears in Collections:01111 医学科

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