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http://hdl.handle.net/10564/909
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| Title: | The Biology of Heat-induced DNA Double-Strand Breaks |
| Authors: | Mori, Eiichiro
Takahashi, Akihisa
Ohnishi, Takeo |
| Keywords: | hyperthermia
DNA double-strand break
γH2AX
endogenous DNA damage |
| Issue Date: | 2006 |
| Publisher: | 日本ハイパーサーミア学会 |
| Citation: | Thermal Medicine Vol. 24 (2008) , No. 2 pp.39-50 |
| Abstract: | Hyperthermia is widely used to treat patients with various types of cancers. However, the molecular mechanisms involved in heat-induced cell killing are not yet fully understood. Although protein denaturation is known to be a major type of damage caused by heat treatment, recent work has revealed that DNA double-strand breaks (DSBs) play important roles in heat-induced cell killing. The aim of this review is to specifically examine the formation and repair of DSBs and their role in heat sensitivity and thermotolerance. |
| Description: | 著作権者：日本ハイパーサーミア学会
日本ハイパーサーミア学会及び著作者の許諾を得て登録 |
| URI: | http://hdl.handle.net/10564/909 |
| ISSN: | 09112529 |
| Appears in Collections: | 011 医学科
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Files in This Item:
| File |
Description |
Size | Format |
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| Thermal Medicine 2008 24(2) p.39-50（掲載可）.pdf | | 370Kb | Adobe PDF | View/Open |
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