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Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/908

Title: What is the Critical Hyperthermia Target in Cancer Cells?
Authors: Takahashi, Akihisa
Ohnishi, Takeo
Keywords: hyperthermia
cell killing
protein denaturation
γH2AX
double-strand break
Issue Date: 2006
Publisher: 日本ハイパーサーミア学会
Citation: 日本ハイパーサーミア学会誌 = Japanese journal of hyperthermic oncology Vol. 22 (2006) , No. 4 pp.229-237
Abstract: Currently, the molecular mechanisms involved in heat-induced cell killing are not completely understood, although protein denaturation is known to be the major target for hyperthermia in cancer cells. A new hypothesis is described here which proposes that heat-induced cell killing is associated with cellular DNA double-strand break (DSB) formation. This review provides details of this model for hyperthermia cell killing, and a possible mechanism to explain heat-induced DSB formation.
Description: 著作権者:日本ハイパーサーミア学会
日本ハイパーサーミア学会及び著作者の許諾を得て登録
URI: http://hdl.handle.net/10564/908
ISSN: 09112529
Appears in Collections:01111 医学科

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