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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.53 No.5-6 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/86
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| Title: | N-nitr osobis(2-oxopr opyl)amineによるハムスター膵管癌発生に対するウシおよびサメ軟骨水抽出物の影響 |
| Other Titles: | EFFECTS OF BOVINE AND SHARK CARTILAGE WATER EXTRACTS ON PANCREATIC DUCTAL CARCINOGESIS IN HAMSTERS |
| Authors: | 村田, 奈保 |
| Keywords: | hamster
pancreas
shark cartilage
chemoprevention |
| Issue Date: | 31-Dec-2002 |
| Publisher: | 奈良医学会 |
| Citation: | Journal of Nara Medical Association Vol.53 No.5-6 p.241-252 |
| Abstract: | Effects of shark cartilage water-extract (SCE) and bovine cartilage water-extract
(BCE) on pancreatic duct carcinogenesis were investigated using a rapid
production model for pancreatic duct carcinoma in hamsters, and the following results
were obtained.
1. SCE inhibited activities of MMP-2 and MMP-9 but BCE did not in vitro.
2. BCE did not have beneficial effects on chemoprevention of pancreatic carcinomas.
3. No toxic signs, including growth retardation or loss of pancreatic and liver weights, were observed in hamsters treated with BOP followed by SCE.
4. The diet containing O.4％ SCE reduced significantly the numbers of adenocarcinomas
and ductallesions．
5. SCE did not affect the BrdU labeling indices of pancreatic ductal lesions.
6. SCE did not affect expression levels of proenzyme form of MMP-2 and MMP-9 and enzyme form of MMP-2 in adenocarcinomas.
These results indicate that SCE possesses inhibitory effects on development of pancreatic carcinomas and that SCE may be a candidate of chemopreventive agent for pancreatic carcinomas. |
| URI: | http://hdl.handle.net/10564/86 |
| ISSN: | 13450069 |
| Appears in Collections: | Vol.53 No.5-6
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| 241-252p.N-nitr osobis(2-oxopr opyl)amineによるハムスター膵管癌発生に対するウシおよびサメ軟骨水抽出物の影響（村田奈保）.pdf | | 1330Kb | Adobe PDF | View/Open |
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