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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.46 No.3 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/824
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| Title: | DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY (DRPLA) AND MIDLATENCY AUDITORY EVOKED RESPONSES |
| Authors: | Kishimoto, Toshifumi
Higashiura, Naoto
Hiraoka, Yukie
Sakiyama, Shinobu
Kirita, Ikuhiro
Noriyama, Yoshinobu
Itoh, Naoto
Ueda, Atsushi
Oribe, Hiroaki
Ikawa, Genro |
| Keywords: | midlatency auditory evoked responses
DRPLA
molecular diagnosis
P1 abnormality |
| Issue Date: | 30-Jun-1995 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.46 No.3 p.251-258 |
| Abstract: | The human 'P1' middle latency evoked potential is postulated to be generat-
ed in the thalamus by a cholinergic component of the ascending reticular activating system.
To test the midbrain function of dentatorubral-pallidoluysian atrophy (DRPLA), recording
of middle latency response to click stimuli were carried out in a DRPLA family which was
detected with the aid of molecular diagnosis. Comparisons between the DRPLA members
and the normal members indicated normal Pa responses but P1 component is abnormal in
DRPLA. This P1 abnormality suggests that the midbrain cholinergic cells in DRPLA may
be dysfunctional. |
| URI: | http://hdl.handle.net/10564/824 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.46 No.3
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Files in This Item:
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| 251-258p.DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY.pdf | | 1071Kb | Adobe PDF | View/Open |
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