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01121 Journal of Nara Medical Association >
Vol.46 No.3 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/822
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Title: | 好酸球における活性化抗原CD69の発現 |
Other Titles: | EXPRESSION OF ACTIVATION ANTIGEN CD69 ON EOSINOPHILS |
Authors: | 森井, 武志 |
Keywords: | bronchoalveolar lavage fluid CD69 eosinophils pleural effusion |
Issue Date: | 30-Jun-1995 |
Publisher: | 奈良医学会 |
Citation: | 奈良医学雑誌 Vol.46 No.3 p.228-240 |
Abstract: | The activation antigen, CD69, has been shown to be expressed on activated
lymphocytes. CD69 has also been shown to be associated with the signal transduction
process. In this study, the author performed flowcytometric analysis of CD69 expression on
eosinophils obtained from the bronchoalveolar lavage fluid (BALF), pleural effusion, or
peripheral blood (PB) of various patients. Whatever the diseases were, lung eosinophils
obtained from BALF or pleural effusion expressed significant levels of CD69, whereas most
PB eosinophils did not express CD69. Further, CD69 expression was induced on PB
eosinophils by the activation of interleukin-3 (IL-3), IL-5, granulocyte macrophage colony
stimulating factor (GM-CSF), interferon-a (IFN-α) and phorbol myristate acetate (PMA),
but platelet activating factor (PAF) did not induce CD69 expression. CD69 expression
induced by IL-3 or GM-CSF was in a dose and time dependent manner. The expression
could be induced significantly at low concentration of 10 pg/ml and was detected after
stimulation for two hours. These findings suggest that CD69 expressions are restricted to
local eosinophils, and that local eosinophils may stand at a different activating state from
PB eosinophils. |
URI: | http://hdl.handle.net/10564/822 |
ISSN: | 04695550 13450069 |
Appears in Collections: | Vol.46 No.3
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