動脈硬化性血管障害患者の尿中微量蛋白排泄量

Abstract

Urinary excretion of microproteins was evaluated at different ages in patients with atherosclerotic vascular complications including ischemic heart disease, cerebrovascular disease and atherosclerosis obliterance. Two hundred-five patients (148 males and 57 females) ranging from 40 to 79 years of age were divided into the 4 age groups in each gender ; 40s, 50s, 60s and 70s, respectively. Patients with overt proteinuria or with a serum creatinine level above normal limits were excluded from the study. Diabetes mellitus and severe hypertensive cases were also excluded. Urinary albumin excretion was significantly increased only in the 70s group as compared with the 50s and 60s groups in males, but was similar in each age group in females. There was no difference in albumin excretion between males and females. Urinary excretions of α1-microglobulin , β2- microglobulin and N-acetyl-β-D-glucosaminidase were not changed with age, and no signifi- cant difference in these parameters was found between the genders. Serum creatinine level showed no change with increasing age. Both urinary excretion of creatinine and values of creatinine clearance showed atendency to decrease with increasing age. These data suggest that urinary excretion of microproteins is not influenced by aging and gender in patients with atherosclerotic vascular complications.