原発性両側乳癌の1例

Abstract

A 49-year-old female who had noticed hard tumors in bilateral breasts visited our hospital. There were depression of nipples and Delle needle biopsy revealed Group Ⅴ for both tumors. Bone scan showed abmormal accumulation in the sternum and bilateral lower ribs. Bone metastasis was suspected. Auchincloss method was performed for bilateral breasts simultaneously because of the advanced stage of cancers and suspected bone metastasis. Histopathologically both lesions were diagnosed as primary bilateral breast carcinoma. We examined hormone recepters, DNA ploidy, amplification of c-myc and c-erbB-2 genes and loss of heterozygosity (LOH) of p 53 and chromosome 16 q, 17 p in bilateral breast tissues. These results showed that the right breast tumor was estrogen recepter-positive, progesteron recepter-negative and of DNA diploidy pattern, while the left breast tumor was estrogen recepter-positive, progesteron recepter-positive and of DNA aneuploidy pattern. Amplification of c-myc and c-erbB-2 and LOH of p 53 and chromosome 16 q, 17 p were not detected in both lesions.