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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.46 No.1 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/797
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| Title: | EFFECT OF DIETARY N-3 AND N-6 POLYUNSATURATED FATTY ACIDS ON LIVER METASTASIS OF HUMAN COLONIC ADENOCARCINOMAS IN NUDE MICE |
| Authors: | Ueyama, Naoto |
| Keywords: | n-3/n-6 ratio
human colonic adenocarcinoma
intrasplenic transplantation
nude mouse
TXA2/PGI2 ratio |
| Issue Date: | 28-Feb-1995 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.46 No.1 p.41-52 |
| Abstract: | Nude mice at 4-6weeks of age were fed diets containing 10% oil with
different α-linolenic acid (α-LnA, n-3)/linoleic acid (LA, n-6) ratios ; Group A (n-3/n-6
=0.01), Group B (0.30), GroupC (0.87) and GroupD (3.37). After 10 days, each dietary
group of mice received intrasplenic (i.s.) transplantation of human colonic adenocar-
cinomas and was fed the same diet. Animals were sacrificed at 3 weeks after i.s. transplan-
tation of COL 5 with a higher'metastatic potential and at 2 months in the case of COL 4 with
a lower metastatic potential. The incidence of liver metastasis and the average number of
metastatic nodules per mouce decreased in the order of Groups B＜C＜D, A. Dietary α-LnA
(n-3)/LA (n-6) ratio was reflected mainly in eicosapentaenoate (EPA, n-3)/arachidonate
(AA, n-6) ratio in the phospholipid fractions and mainly in α-LnA (n-3)/LA (n-6) ratio
in the triacylglycerol fractions from both the non-cancerous referertce tissues and the
metastatic tumor tissues in liver, similarly. The thromboxane (TX) A2 and prostaglandin
(PG) I2 levels decreased along with the increase in EPA/AA ratio of phospholipids, but the
TXA2/PGI2 ratio was the highest and the bleeding time was the shortest in Group B as
compared with the other dietary groups. Thus, the metastatic potential of intrasplenically
transplanted human colonic carcinoma cells was positively correlated with both the TXA2
/PGI2 ratio in liver and thrombotic tendency, but not with dietary α-LnA/LA ratios in nude
mice. |
| URI: | http://hdl.handle.net/10564/797 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.46 No.1
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| 041-052p.EFFECT OF DIETARY N-3 AND N-6 POLYUNSATURATED.pdf | | 1140Kb | Adobe PDF | View/Open |
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