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Vol.46 No.1 >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10564/796

Title: HIGH FLOW DOES NOT ABOLISH THE REDUCED MAXIMUM OXYGEN UPTAKE IN DOG MUSCLE PERFUSED WITH 2, 3-DIPHOSPHOGLYCERATE-DEPLETED BLOOD
Authors: Kohzuki, Hisaharu
Enoki, Yasunori
Sakata, Susumu
Shimizu, Satoshi
Hattori, Masatoshi
Keywords: erythrocyte
exercise
gastrocnemius
oxygen dissociation curve
oxygen uptake
Issue Date: 28-Feb-1995
Publisher: 奈良医学会
Citation: 奈良医学雑誌 Vol.46 No.1 p.31-40
Abstract: To clarify the limiting factors for maximum oxygen consumption (⩒ₒ₂max) in contracting skeletal muscle, we perfused isolated dog gastrocnemius muscle at a high flow rate with two kinds of blood which have different affinities for oxygen. ⩒ₒ₂max was decreased significantly in the perfusion with DPG-depleted blood and the reduction was shown to have resulted from a lower O₂ extraction ratio. ⩒ₒ₂ and O₂ extraction were closely proportional to the reciprocal of resistance to blood flow. Furthermore, the different O₂ affinities of the perfusion blood affected these relationships : the slopes for ⩒ₒ₂ and O₂ extraction against the reciprocal of resistance for DPG-restored blood were signifi- cantly higher than those for DPG-depleted blood. We assumed that red cell transit time is inversely proportional to the resistance to blood flow and that high O₂-affinity blood is inherently slow to unload O₂ from red cells. The present results are well explained by our assumption. The results suggest that ⩒ₒ₂max may be determined by red cell transit time and O₂ unloading from the red cell.
URI: http://hdl.handle.net/10564/796
ISSN: 04695550
13450069
Appears in Collections:Vol.46 No.1

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