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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.46 No.1 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/796
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| Title: | HIGH FLOW DOES NOT ABOLISH THE REDUCED MAXIMUM OXYGEN UPTAKE IN DOG MUSCLE PERFUSED WITH 2, 3-DIPHOSPHOGLYCERATE-DEPLETED BLOOD |
| Authors: | Kohzuki, Hisaharu
Enoki, Yasunori
Sakata, Susumu
Shimizu, Satoshi
Hattori, Masatoshi |
| Keywords: | erythrocyte
exercise
gastrocnemius
oxygen dissociation curve
oxygen uptake |
| Issue Date: | 28-Feb-1995 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.46 No.1 p.31-40 |
| Abstract: | To clarify the limiting factors for maximum oxygen consumption (Vo2max)
in contracting skeletal muscle, we perfused isolated dog gastrocnemius muscle at a high
flow rate with two kinds of blood which have different affinities for oxygen. Vo2max was
decreased significantly in the perfusion with DPG-depleted blood and the reduction was
shown to have resulted from a lower O2 extraction ratio. Vo2 and O2 extraction were
closely proportional to the reciprocal of resistance to blood flow. Furthermore, the
different O2 affinities of the perfusion blood affected these relationships : the slopes for Vo2
and O2 extraction against the reciprocal of resistance for DPG-restored blood were signifi-
cantly higher than those for DPG-depleted blood. We assumed that red cell transit time is
inversely proportional to the resistance to blood flow and that high O2-affinity blood is
inherently slow to unload O2 from red cells. The present results are well explained by our
assumption. The results suggest that Vo2max may be determined by red cell transit time and
O2 unloading from the red cell. |
| URI: | http://hdl.handle.net/10564/796 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.46 No.1
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Files in This Item:
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| 031-040p.HIGH FLOW DOES NOT ABOLISH THE REDUCED MAXIMUM OXYGEN UPTAKE IN DOG.pdf | | 1095Kb | Adobe PDF | View/Open |
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