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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.46 No.1 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/795
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| Title: | RAYNAUD'S SYNDROME IMPROVED BY THE INTRAVENOUS ADMINISTRATION OF A THROMBOXANE SYNTHETASE INHIBITOR |
| Authors: | Tsuchihashi, Masayuki
Tsunoda, Shigeru
Kitaoka, Soichi
Morita, Yasuhiro
Yumura, Fumitoshi
Yoshida, Kazumasa
Hayashi, Masafumi
Ariyoshi, George
Dohi, Kazuhiro |
| Keywords: | prostacyclin
Raynaud's syndrome
sodium ozagrel
thromboxane synthetase inhibitor
thromboxane A2 |
| Issue Date: | 28-Feb-1995 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.46 No.1 p.25-30 |
| Abstract: | A 66-year-old man with multiple cerebral infarctions was treated with
sodium ozagral ; this was associated with an improvement in his Raynaud's syndrome
attributable to vibration-induced white finger disease. Sodium ozagrel selectively inhibits
thromboxane synthetase, reducing thromboxane A2 (TXA2) and also slightly increasing
prostacyclin (PGI2) ; this leads to vasodilatation and the inhibition of platelet aggregation.
An imbalance between TXA2 and PGI2 caused by vascular endothelial injury is thought to
cause Raynaud's phenomenon. Sodium ozagrel appears to improve the symptoms of
Raynaud's syndrome by relatively increasing PGI2, thus correcting the imbalance. Ozagrel,
which currently is being used to treat cerebral thrombosis and bronchial asthma, as well as
to improve vasospasm following subarachnoid hemorrhage, also may provide effective
relief in patients with Raynaud's syndrome. |
| URI: | http://hdl.handle.net/10564/795 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.46 No.1
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| 025-030p.RAYNAUD'S SYNDROME IMPROVED BY THE INTRAVENOUS ADMINISTRATION.pdf | | 1205Kb | Adobe PDF | View/Open |
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