血中CA 19-9, DUPAN-2, SPan-1値が異常高値を示したMirizzi症候群の1例

Abstract

A 43-year-old woman was seen at the hospital because of rihgt hypochon- dralgia. No jaundice and fever were noted. On blood examination CA 19-9, DUPAN-2, and SPan-1 were as high as 1200 U/ml, 930 U/ml, and 270 U/ml, respectively. Ultrasonography and CT revealed a swollen gallbladder and one stone each in the fundus and neck. No SOL was confimed in the liver, gallbladder, and pancreas. ERCP disclosed a picture of Mirizzi syndrome and no malignant findings were revealed with abdominal angiography. Lapar- otomy was performed and dislocation of the common hepatic duct due to incarcerated stone into the cystic duct was found, but no tumor was seen. Cholecystectomy was carried out. No histologic malignancy was also detected. We often experience a case of benign biliary disease with a mild increase in a tumor marker, but rarely encounter a case of the disease with simultaneous and abnormally great increases in several tumor markers. This paper also presents a view of the literature.