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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.47 No.6 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/759
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| Title: | C型慢性肝炎に対するIFN療法後にネフローゼ症候群を発症した1例 |
| Other Titles: | A CASE OF NEPHROTIC SYNDROME AFTER ALPHA INTERFERON THERAPY FOR CHRONIC HEPATITIS C |
| Authors: | 山本, 雄太
山野, 繁
岩野, 正之
椎木, 英夫
土肥, 和紘 |
| Keywords: | cryoglobulin |
| Issue Date: | 31-Dec-1996 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.47 No.6 p.325-330 |
| Abstract: | A 55-year-old female presenting with nephrotic syndrome one month after
alpha interferon therapy for chronic hepatitis type C is reported. Leg edema and abdominal
fullness appeared 1 month after alpha interferon therapy. Urinalysis revealed 4.8 g/day of
proteinuria. Laboratory examinations disclosed hypoalbuminemia (1.9 g/dl), positive for
HCV antibody and HCV-RNA. Cryoglobulins could not be found. Light microscopic
findings of renal biopsy revealed mild expansion of the mesangial area and spike-like
structure along the outer aspect of capillary walls. Immunofluorescent examination of the
renal biopsy demonstrated granular staining of IgG along the capillary walls. She was
diagnosed as having nephrotic syndrome due to membranous nephropathy. She was treated
with oral administration of predonisolone in an initial dosage of 30 mg/day and cyclophos-
phamide in an initial dosage of 50 mg/day. The therapy was markedly effective for this
case.
We discuss the relationship among HCV, interferon, and nephrotic syndrome. |
| URI: | http://hdl.handle.net/10564/759 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.47 No.6
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| 325-330p.C型慢性肝炎に対するIFN療法後にネフローゼ症候群を発症した1例.pdf | | 1610Kb | Adobe PDF | View/Open |
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