IFN-α療法中にネフローゼ症候群を呈したHBV関連腎炎の1例

Abstract

A 31-year-old man with chronic active hepatitis (hepatitis B) was referred to our hospital for the further evaluation of proteinuria. Renal biopsy findings showed membranoproliferative glomerulonephritis which was compatible with hepatitis B ne- phropathy. Interferon-ev (IFN) was administrated for the hepatitis. On the 27 th treatment day, the patient revealed nephrotic syndrome, with massive proteinuria (6.5 g/day) and hypoalbuminemia (2.7 g/dl). After IFN therapy was stopped, serum albumin soon in- creased to the level berore treatment (3.5 g/dl). Nephrotic syndrome was, therefore, proved to be an adverse effect of IFN therapy. Thus, nephrotic syndrome should not be overlooked during IFN therapy for hepatitis B nephropathy.