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GINMU >
03 紀要 >
031 Journal of Nara Medical Association >
Vol.47 No.2 >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10564/715
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| Title: | EPINEPHRINE INDUCES 72-kD HEAT SHOCK PROTEIN (HSP72) IN CULTURED HUMAN FIBROBLASTS |
| Authors: | Hatoko, Mitsuo
Tada, Hideyuki
Kuwahara, Masamitsu
Muramatsu, Tsutomu
Shirai, Toshihiko |
| Keywords: | stress protein
HSP 72
epinephrine
fibroblast |
| Issue Date: | 30-Apr-1996 |
| Publisher: | 奈良医学会 |
| Citation: | 奈良医学雑誌 Vol.47 No.2 p.187-197 |
| Abstract: | In order to know the stress response of cells to epinephrine, we examined
the induction of 72-kD protein (HSP 72) in cultured human fibroblasts using an immuno-
fluorescence method. HSP 72 was induced strongly and rapidly after epinephrine treatment
at a final concentration of 2.7×10^-5 M which corresponds to the concentration of clinical
use. When propranolol (1×10^-4 M) was added to a culture medium containing epinephrine,
the onset and peak of HSP 72 induction of fibroblasts were delayed compared to those
observed after epinephrine treatment alone.
These results suggest that epinephrine is actually a potent inducer of HSP 72 and that the
cells are stressed by epinephrine at a concentration of routine use in surgery. Furthermore,
the induction of HSP 72 by epinephrine is considered to be related to its β-adrenergic
actlon. |
| URI: | http://hdl.handle.net/10564/715 |
| ISSN: | 04695550
13450069 |
| Appears in Collections: | Vol.47 No.2
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Files in This Item:
| File |
Description |
Size | Format |
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| 187-197p.EPINEPHRINE INDUCES 72-kD HEAT SHOCK PROTEIN.pdf | | 1914Kb | Adobe PDF | View/Open |
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