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GINMU >
01 奈良県立医科大学 >
011 医学部 >
0112 紀要 >
01121 Journal of Nara Medical Association >
Vol.47 No.2 >
このアイテムの引用には次の識別子を使用してください:
http://hdl.handle.net/10564/713
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タイトル: | 二次性上皮小体機能亢進症における上皮小体摘除術前後の血清ピリジノリン類の経時的検討 |
その他のタイトル: | SERIAL MEASUREMENT OF SERUM PYRIDINIUM CROSSLINKS BEFORE AND AFTER PARATHYROIDECTOMY IN PATIENTS WITH SECONDARY HYPERPARATHYROIDISM |
著者: | 影林, 頼明 三馬, 省二 米田, 龍生![](/dspace/image/metalink/link_ja.gif) 大山, 信雄 吉田, 克法![](/dspace/image/metalink/link_ja.gif) 窪田, 一男 丸山, 良夫 大園, 誠一郎 本宮, 善恢 平尾, 佳彦![](/dspace/image/metalink/link_ja.gif) 岡島, 英五郎 |
キーワード: | secondary hyperparathyroidism serum pyridinium crosslinks postoperative sequential changes parathyroidectomy bone metabolic markers |
発行日: | 1996年4月30日 |
出版者: | 奈良医学会 |
引用: | 奈良医学雑誌 Vol.47 No.2 p.167-173 |
抄録: | To investigate the clinical usefulness of pyridinium crosslinks, pyridinoline
(Pyr)and deoxypyridinoline (Dpyr), novel markers of bone resorption, in evaluation of the
state of renal osteodystrophy (ROD), serum concentrations of the crosslinks together with
other known ROD markers were measured sequentially in patients with secondary hyper-
parathyroidism (2°HPT) before and after parathyroidectomy (PTX).
In six chronic hemodialysis patients with 2°HPT who underwent PTX and autotrans-
plantation of a resected parathyroid gland from January through August 1994, serial
measurement of serum Pyr, Dpyr, HS-PTH, alkaline phosphatase and osteocalcin was
done. Similarly, serial measurement of urinary Pyr, Dpyr and other markers was done in
two surgically-treated patients with primary hyperparathyroidism (1°HPT). The changes
of these markers were evaluated in each patient and between the patients'with 1°HPT and
2°HPT.
Before PTX, marked elevation of ROD markers including Pyr and Dpyr and severe bone
changes indicative of the advanced ROD stage on plain X-ray films were observed in all
patients with 2°HPT. The changes of Pyr after PTX were parallel to those of Dpyr.
However, the reducing speed of Pyr and Dpyr varied among the patients : patients with
lower Pyr and Dpyr levels before PTX showed a slower decrease of the crosslinks. All
patients out of three in whom serial measurement of the markers in the early phase after
PTX was done, alkaline phosphatase and/or osteocalcin showed a transient elevation
without changes of Pyr and Dpyr levels. In pabients, the changes of alkaline phosphatase,
osteocalcin and the crosslinks were parallel from three months after PTX. The similar
changes of the markers including urinary Pyr and Dpyr to in patients with 2°HPT were
observed in two patients with 1°HPT.
The data suggest that the state of high turnover bone in 2°HPT would be improved
associating with a decrease of PTH secretion after PTX, and bone formation might become
dominant in the process of bone remodeling in the early phase after PTX. It is concluded
that serial measurement of serum pyridinium crosslinks before and after PTX would be
useful in evaluation of changes of ROD lesions in patients with 2°HPT. |
URI: | http://hdl.handle.net/10564/713 |
ISSN: | 04695550 13450069 |
出現コレクション: | Vol.47 No.2
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